The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study
Abstract Background The number of lymph nodes to be removed during tumor resection in patients with intrahepatic cholangiocarcinoma (ICC) has always been a subject of controversy. The correlation between examined lymph nodes (ELN) and cancer-specific mortality (CSM) in individuals with ICC was the p...
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| Format: | Article |
| Language: | English |
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Springer
2025-04-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02322-8 |
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| author | Chaojia Ou Yufan Zhou You Tang Zhiguo Tan Chuang Peng Xu Chen Ou Li |
| author_facet | Chaojia Ou Yufan Zhou You Tang Zhiguo Tan Chuang Peng Xu Chen Ou Li |
| author_sort | Chaojia Ou |
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| description | Abstract Background The number of lymph nodes to be removed during tumor resection in patients with intrahepatic cholangiocarcinoma (ICC) has always been a subject of controversy. The correlation between examined lymph nodes (ELN) and cancer-specific mortality (CSM) in individuals with ICC was the purpose of this investigation. Methods Multivariable models were used to analyze data from the Surveillance, Epidemiology, and End Results database on ICC in order to ascertain the connection between ELN count and CSM. Correlation between ELN and cancer-specific survival (CSS) was evaluated by restricted cubic splines (RCS) on a continuous scale. Locally weighted scatterplot smoothing smoother was used to evaluated the hazard ratios (HRs) of ELNs for CSS with the structural breakpoints determined by Chow test. Results This investigation incorporated 1335 ICC cases. Independent risk factors for CSM included median household income, race, diagnostic year, tumor grade, clinical stage, pT stage, pN stage, pM stage and ELN count. With the adjustment for covariates, ICC cases showed statistically significant improvements in CSS (HR = 0.88) as the ELN count increased. The best threshold ELN count, as determined by cut-point analysis, was 6, which allowed for accurate CSS probability discrimination. Conclusion Increasing ELN count indicated better CSS. Our results strongly suggested 6 ELNs as the optimal cut-off number for assessing the standard of lymph node inspection and prognostic classification in ICC. |
| format | Article |
| id | doaj-art-0dc73259f0904b1e87fbf9da1775df7e |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-0dc73259f0904b1e87fbf9da1775df7e2025-08-20T02:17:50ZengSpringerDiscover Oncology2730-60112025-04-0116111010.1007/s12672-025-02322-8The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based studyChaojia Ou0Yufan Zhou1You Tang2Zhiguo Tan3Chuang Peng4Xu Chen5Ou Li6Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of General Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityThe First School of Clinical Medicine, Lanzhou UniversityDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal UniversityAbstract Background The number of lymph nodes to be removed during tumor resection in patients with intrahepatic cholangiocarcinoma (ICC) has always been a subject of controversy. The correlation between examined lymph nodes (ELN) and cancer-specific mortality (CSM) in individuals with ICC was the purpose of this investigation. Methods Multivariable models were used to analyze data from the Surveillance, Epidemiology, and End Results database on ICC in order to ascertain the connection between ELN count and CSM. Correlation between ELN and cancer-specific survival (CSS) was evaluated by restricted cubic splines (RCS) on a continuous scale. Locally weighted scatterplot smoothing smoother was used to evaluated the hazard ratios (HRs) of ELNs for CSS with the structural breakpoints determined by Chow test. Results This investigation incorporated 1335 ICC cases. Independent risk factors for CSM included median household income, race, diagnostic year, tumor grade, clinical stage, pT stage, pN stage, pM stage and ELN count. With the adjustment for covariates, ICC cases showed statistically significant improvements in CSS (HR = 0.88) as the ELN count increased. The best threshold ELN count, as determined by cut-point analysis, was 6, which allowed for accurate CSS probability discrimination. Conclusion Increasing ELN count indicated better CSS. Our results strongly suggested 6 ELNs as the optimal cut-off number for assessing the standard of lymph node inspection and prognostic classification in ICC.https://doi.org/10.1007/s12672-025-02322-8Intrahepatic cholangiocarcinomaLymph nodesCancer-specific deathSeer |
| spellingShingle | Chaojia Ou Yufan Zhou You Tang Zhiguo Tan Chuang Peng Xu Chen Ou Li The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study Discover Oncology Intrahepatic cholangiocarcinoma Lymph nodes Cancer-specific death Seer |
| title | The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study |
| title_full | The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study |
| title_fullStr | The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study |
| title_full_unstemmed | The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study |
| title_short | The optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma: a population-based study |
| title_sort | optimal number of examined lymph nodes for cancer specific death of intrahepatic cholangiocarcinoma a population based study |
| topic | Intrahepatic cholangiocarcinoma Lymph nodes Cancer-specific death Seer |
| url | https://doi.org/10.1007/s12672-025-02322-8 |
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