Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus. This study investigated the influence of the SP on Env antigenicity and imm...

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Bibliographic Details
Main Authors: Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, J. Andrew Duty
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
HIV-1 vaccine
HIV-1 envelope
signal peptide
glycosylation
antigenicity
immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1476924/full
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