Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations
Intensive research of bacterial toxin-antitoxin systems (TAS) in recent decades has significantly expanded and deepened knowldge about them. As TAS modules were first discovered in the plasmids and later in the chromosomes of bacteria, and after subsequent study of their specific regulation of activ...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/77 |
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| author | B. G. Andryukov N. N. Besednova T. S. Zaporozhets M. P. Bynina |
| author_facet | B. G. Andryukov N. N. Besednova T. S. Zaporozhets M. P. Bynina |
| author_sort | B. G. Andryukov |
| collection | DOAJ |
| description | Intensive research of bacterial toxin-antitoxin systems (TAS) in recent decades has significantly expanded and deepened knowldge about them. As TAS modules were first discovered in the plasmids and later in the chromosomes of bacteria, and after subsequent study of their specific regulation of activation and functions, their image has changed from simple curious genetic objects to one of the most important tools. They play a decisive role in bacterial protection and adaptation to unfavorable growth conditions, including microbial persistence and chronic infection processes, formation of antibiotic resistance. It became clear that these small genetic modules, which can be found almost everywhere in the bacterial genomes, have a high potential for biotechnological and biomedical innovation research, as well as the prospect of developing fundamentally new antibacterial technologies. Given the leading role of TAS for the survival of pathogenic bacteria and the development of the infectious process, modern technologies for creating alternative antibacterial strategies consider these systems to be promising targets for the development of new antimicrobial agents. |
| format | Article |
| id | doaj-art-0dbfea73e5094be593ad818bb51633cb |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-0dbfea73e5094be593ad818bb51633cb2025-08-20T03:57:47ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01633-4505876Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial PreparationsB. G. Andryukov0N. N. Besednova1T. S. Zaporozhets2M. P. Bynina3G.P. Somov Research Institute of Epidemiology and Microbiology; Far Eastern Federal UniversityG.P. Somov Research Institute of Epidemiology and MicrobiologyG.P. Somov Research Institute of Epidemiology and MicrobiologyG.P. Somov Research Institute of Epidemiology and MicrobiologyIntensive research of bacterial toxin-antitoxin systems (TAS) in recent decades has significantly expanded and deepened knowldge about them. As TAS modules were first discovered in the plasmids and later in the chromosomes of bacteria, and after subsequent study of their specific regulation of activation and functions, their image has changed from simple curious genetic objects to one of the most important tools. They play a decisive role in bacterial protection and adaptation to unfavorable growth conditions, including microbial persistence and chronic infection processes, formation of antibiotic resistance. It became clear that these small genetic modules, which can be found almost everywhere in the bacterial genomes, have a high potential for biotechnological and biomedical innovation research, as well as the prospect of developing fundamentally new antibacterial technologies. Given the leading role of TAS for the survival of pathogenic bacteria and the development of the infectious process, modern technologies for creating alternative antibacterial strategies consider these systems to be promising targets for the development of new antimicrobial agents.https://www.antibiotics-chemotherapy.ru/jour/article/view/77toxin-antitoxin systemantibacterial resistanceantibiotic therapyalternatives |
| spellingShingle | B. G. Andryukov N. N. Besednova T. S. Zaporozhets M. P. Bynina Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations Антибиотики и Химиотерапия toxin-antitoxin system antibacterial resistance antibiotic therapy alternatives |
| title | Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations |
| title_full | Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations |
| title_fullStr | Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations |
| title_full_unstemmed | Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations |
| title_short | Bacterial Toxin-Antitoxin Systems and New Strategies for Creating Antibacterial Preparations |
| title_sort | bacterial toxin antitoxin systems and new strategies for creating antibacterial preparations |
| topic | toxin-antitoxin system antibacterial resistance antibiotic therapy alternatives |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/77 |
| work_keys_str_mv | AT bgandryukov bacterialtoxinantitoxinsystemsandnewstrategiesforcreatingantibacterialpreparations AT nnbesednova bacterialtoxinantitoxinsystemsandnewstrategiesforcreatingantibacterialpreparations AT tszaporozhets bacterialtoxinantitoxinsystemsandnewstrategiesforcreatingantibacterialpreparations AT mpbynina bacterialtoxinantitoxinsystemsandnewstrategiesforcreatingantibacterialpreparations |