Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial
BackgroundMetabolic syndrome (MetS) represents a constellation of metabolic abnormalities. Perirenal fat is a type of visceral fat surrounding the kidneys and possesses distinct anatomical and physiological features. This study aims to investigate the association between perirenal fat volume (PrFV)...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1557701/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849715165509976064 |
|---|---|
| author | Yang Hua Meng-Huan Li Meng-Huan Li Yu-Xuan Lou Ke-Rui Zhang Jia-Ming Yang Yan-Hui Sheng Yu-Qing Zhang Chuan-li Cheng Chao Zou Ting-ting Wu Xiang-Qing Kong Xiang-Qing Kong Wei Sun Wei Sun |
| author_facet | Yang Hua Meng-Huan Li Meng-Huan Li Yu-Xuan Lou Ke-Rui Zhang Jia-Ming Yang Yan-Hui Sheng Yu-Qing Zhang Chuan-li Cheng Chao Zou Ting-ting Wu Xiang-Qing Kong Xiang-Qing Kong Wei Sun Wei Sun |
| author_sort | Yang Hua |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome (MetS) represents a constellation of metabolic abnormalities. Perirenal fat is a type of visceral fat surrounding the kidneys and possesses distinct anatomical and physiological features. This study aims to investigate the association between perirenal fat volume (PrFV) and MetS in Chinese adults.MethodsWe conducted a post-hoc cross-sectional analysis within a multicenter, randomized clinical trial. Demographic information, anthropometric data and laboratory tests were obtained from the electronic data capture system. PrFV was assessed and measured by ultrasonography. Subcutaneous and visceral fat volume were quantified by abdominal MRI. Individuals were categorized according to PrFV tertiles, and Spearman correlation analysis was performed to investigate the correlation between PrFV and metabolic profiles. Adjusted multivariable regression models were employed to investigate the relationship of PrFV with MetS. The receiver operating characteristic curve was used to identify the value of PrFV for predicting MetS.ResultsAmong 100 enrolled subjects, the median age was 50.0 (40.0-60.0) years, and 75% were male. Spearman correlation analysis revealed significant positive correlations between PrFV and total cholesterol (r = 0.24, P = 0.02), triglycerides (r = 0.32, P = 0.001), LDL-C (r = 0.21, P = 0.04), diastolic blood pressure (r = 0.24, P = 0.02), BMI (r = 0.39, P < 0.001), waist circumference (r = 0.39, P < 0.001), and uric acid (r = 0.40, P < 0.001). In the fully-adjusted multivariable regression model, individuals in the highest tertile of PrFV exhibited a higher risk of MetS (Odds ratio = 4.48, 95% Confidence interval: 1.25-17.6). The area under the curve (AUC) of PrFV for predicting MetS was higher than subcutaneous and visceral fat volume.ConclusionIncreased PrFV was positively associated with a higher risk of MetS in Chinese adults. Perirenal fat may serve as a surrogate marker and potential therapeutic target for MetS.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT 05049096. |
| format | Article |
| id | doaj-art-0dbee71782df4a0e9eb356bc6ffcd2e4 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0dbee71782df4a0e9eb356bc6ffcd2e42025-08-20T03:13:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15577011557701Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trialYang Hua0Meng-Huan Li1Meng-Huan Li2Yu-Xuan Lou3Ke-Rui Zhang4Jia-Ming Yang5Yan-Hui Sheng6Yu-Qing Zhang7Chuan-li Cheng8Chao Zou9Ting-ting Wu10Xiang-Qing Kong11Xiang-Qing Kong12Wei Sun13Wei Sun14Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanchang Medical University, Nanchang, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaCardiovascular Research Center, The Affiliated Suzhou Hospital with Nanjing Medical University, Gusu School, Suzhou, ChinaCardiovascular Research Center, The Affiliated Suzhou Hospital with Nanjing Medical University, Gusu School, Suzhou, ChinaCardiovascular Research Center, The Affiliated Suzhou Hospital with Nanjing Medical University, Gusu School, Suzhou, ChinaDepartment of Cardiology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, ChinaPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaCardiovascular Research Center, The Affiliated Suzhou Hospital with Nanjing Medical University, Gusu School, Suzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, ChinaCardiovascular Research Center, The Affiliated Suzhou Hospital with Nanjing Medical University, Gusu School, Suzhou, ChinaBackgroundMetabolic syndrome (MetS) represents a constellation of metabolic abnormalities. Perirenal fat is a type of visceral fat surrounding the kidneys and possesses distinct anatomical and physiological features. This study aims to investigate the association between perirenal fat volume (PrFV) and MetS in Chinese adults.MethodsWe conducted a post-hoc cross-sectional analysis within a multicenter, randomized clinical trial. Demographic information, anthropometric data and laboratory tests were obtained from the electronic data capture system. PrFV was assessed and measured by ultrasonography. Subcutaneous and visceral fat volume were quantified by abdominal MRI. Individuals were categorized according to PrFV tertiles, and Spearman correlation analysis was performed to investigate the correlation between PrFV and metabolic profiles. Adjusted multivariable regression models were employed to investigate the relationship of PrFV with MetS. The receiver operating characteristic curve was used to identify the value of PrFV for predicting MetS.ResultsAmong 100 enrolled subjects, the median age was 50.0 (40.0-60.0) years, and 75% were male. Spearman correlation analysis revealed significant positive correlations between PrFV and total cholesterol (r = 0.24, P = 0.02), triglycerides (r = 0.32, P = 0.001), LDL-C (r = 0.21, P = 0.04), diastolic blood pressure (r = 0.24, P = 0.02), BMI (r = 0.39, P < 0.001), waist circumference (r = 0.39, P < 0.001), and uric acid (r = 0.40, P < 0.001). In the fully-adjusted multivariable regression model, individuals in the highest tertile of PrFV exhibited a higher risk of MetS (Odds ratio = 4.48, 95% Confidence interval: 1.25-17.6). The area under the curve (AUC) of PrFV for predicting MetS was higher than subcutaneous and visceral fat volume.ConclusionIncreased PrFV was positively associated with a higher risk of MetS in Chinese adults. Perirenal fat may serve as a surrogate marker and potential therapeutic target for MetS.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT 05049096.https://www.frontiersin.org/articles/10.3389/fendo.2025.1557701/fullmetabolic syndromeperirenal fatultrasonographyvisceral fatChinese population |
| spellingShingle | Yang Hua Meng-Huan Li Meng-Huan Li Yu-Xuan Lou Ke-Rui Zhang Jia-Ming Yang Yan-Hui Sheng Yu-Qing Zhang Chuan-li Cheng Chao Zou Ting-ting Wu Xiang-Qing Kong Xiang-Qing Kong Wei Sun Wei Sun Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial Frontiers in Endocrinology metabolic syndrome perirenal fat ultrasonography visceral fat Chinese population |
| title | Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial |
| title_full | Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial |
| title_fullStr | Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial |
| title_full_unstemmed | Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial |
| title_short | Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial |
| title_sort | perirenal fat as a potential marker and therapeutic target for metabolic syndrome insights from a multicenter randomized controlled trial |
| topic | metabolic syndrome perirenal fat ultrasonography visceral fat Chinese population |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1557701/full |
| work_keys_str_mv | AT yanghua perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT menghuanli perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT menghuanli perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT yuxuanlou perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT keruizhang perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT jiamingyang perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT yanhuisheng perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT yuqingzhang perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT chuanlicheng perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT chaozou perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT tingtingwu perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT xiangqingkong perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT xiangqingkong perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT weisun perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial AT weisun perirenalfatasapotentialmarkerandtherapeutictargetformetabolicsyndromeinsightsfromamulticenterrandomizedcontrolledtrial |