Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats.
Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effec...
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Interna Publishing
2024-01-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
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| Online Access: | https://ina-jghe.com/index.php/jghe/article/view/918 |
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| author | Muhammad Begawan Bestari Enny Rohmawaty Aziiz Mardanarian Rosdianto Hermin A. Usman Winda A. M. Saragih Ade Zuhrotun Rini Hendriani Yoga Windhu Wardhana Savira Ekawardhani Hesti Lina Wiraswati Nenny Agustanti Sumartini Dewi Muhammad Palar Wijaya |
| author_facet | Muhammad Begawan Bestari Enny Rohmawaty Aziiz Mardanarian Rosdianto Hermin A. Usman Winda A. M. Saragih Ade Zuhrotun Rini Hendriani Yoga Windhu Wardhana Savira Ekawardhani Hesti Lina Wiraswati Nenny Agustanti Sumartini Dewi Muhammad Palar Wijaya |
| author_sort | Muhammad Begawan Bestari |
| collection | DOAJ |
| description | Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.
Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.
Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.
Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions. |
| format | Article |
| id | doaj-art-0db4e3a19c014eb5a1f2f4cf0b9b624a |
| institution | OA Journals |
| issn | 1411-4801 2302-8181 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj-art-0db4e3a19c014eb5a1f2f4cf0b9b624a2025-08-20T02:25:59ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812024-01-0124310.24871/2432023206849Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats.Muhammad Begawan Bestari0Enny Rohmawaty1Aziiz Mardanarian Rosdianto2Hermin A. Usman3Winda A. M. Saragih4Ade Zuhrotun5Rini Hendriani6Yoga Windhu Wardhana7Savira Ekawardhani8Hesti Lina Wiraswati9Nenny Agustanti10Sumartini Dewi11Muhammad Palar Wijaya12Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungDivision of Pharmacology and Therapy, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, BandungVeterinary Medicine Program, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, BandungDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, BandungDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, BandungDepartment of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, BandungDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, BandungStudy Center of Pharmaceutical Dosage Development, Department of Pharmaceutics and Pharmaceuticals Technology, Faculty of Pharmacy, Universitas Padjadjaran, BandungDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, BandungDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, BandungDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungImmunology Study Center, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, BandungDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungBackground: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect. Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels. Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels. Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.https://ina-jghe.com/index.php/jghe/article/view/918antifibroticciplukanfibrosisnafldphysalis angulata |
| spellingShingle | Muhammad Begawan Bestari Enny Rohmawaty Aziiz Mardanarian Rosdianto Hermin A. Usman Winda A. M. Saragih Ade Zuhrotun Rini Hendriani Yoga Windhu Wardhana Savira Ekawardhani Hesti Lina Wiraswati Nenny Agustanti Sumartini Dewi Muhammad Palar Wijaya Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy antifibrotic ciplukan fibrosis nafld physalis angulata |
| title | Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. |
| title_full | Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. |
| title_fullStr | Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. |
| title_full_unstemmed | Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. |
| title_short | Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. |
| title_sort | physalis angulata linn as a potential liver antifibrotic agent in rats |
| topic | antifibrotic ciplukan fibrosis nafld physalis angulata |
| url | https://ina-jghe.com/index.php/jghe/article/view/918 |
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