Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans
Abstract Phosphatidylcholine is a ubiquitous phospholipid. It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. The lev...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85624-9 |
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| author | Michela Palmieri Spyridoula Maraka Horace J. Spencer Jeff D. Thostenson Katherine Dishongh Micheal Knox Betty Ussery Jesse Byrd Jacqueline K. Kuipers Sanaz Abedzadeh-Anaraki Chitharanjan Duvoor Yuanjie Mao Lakshmi Menon James S. Williams Stavros C. Manolagas Robert L. Jilka Elena Ambrogini |
| author_facet | Michela Palmieri Spyridoula Maraka Horace J. Spencer Jeff D. Thostenson Katherine Dishongh Micheal Knox Betty Ussery Jesse Byrd Jacqueline K. Kuipers Sanaz Abedzadeh-Anaraki Chitharanjan Duvoor Yuanjie Mao Lakshmi Menon James S. Williams Stavros C. Manolagas Robert L. Jilka Elena Ambrogini |
| author_sort | Michela Palmieri |
| collection | DOAJ |
| description | Abstract Phosphatidylcholine is a ubiquitous phospholipid. It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. The levels of anti-PC IgM increase as the levels of PC-OxPLs increase and, in humans, are inversely correlated with the incidence of cardiovascular diseases and steatohepatitis. PC-OxPLs also decrease bone mass in mice. Overexpression of anti-PC IgM ameliorates atherosclerosis and steatohepatitis, increases bone mass in young mice, and protects against high fat diet- and age-associated osteoporosis. We investigated the relationship between anti-PC IgM plasma levels and bone mineral density (BMD) in a cross-sectional study of 247 participants [mean age: 65.5 (± 8.6) years] without medical conditions known to influence BMD or antibody production. Anti-PC IgM levels negatively correlated with both T- and Z-scores at the lumbar spine, femur and, to a lesser extent, the forearm. These correlations were maintained after adjustment for age, race, and sex. These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis. |
| format | Article |
| id | doaj-art-0db35bdfd9ce4f45a5084cdcc0ec4931 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0db35bdfd9ce4f45a5084cdcc0ec49312025-01-19T12:22:47ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-85624-9Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humansMichela Palmieri0Spyridoula Maraka1Horace J. Spencer2Jeff D. Thostenson3Katherine Dishongh4Micheal Knox5Betty Ussery6Jesse Byrd7Jacqueline K. Kuipers8Sanaz Abedzadeh-Anaraki9Chitharanjan Duvoor10Yuanjie Mao11Lakshmi Menon12James S. Williams13Stavros C. Manolagas14Robert L. Jilka15Elena Ambrogini16Division of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesDivision of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesDepartment of Biostatistics, University of Arkansas for Medical SciencesDepartment of Biostatistics, University of Arkansas for Medical SciencesCentral Arkansas Veterans Healthcare SystemCentral Arkansas Veterans Healthcare SystemCentral Arkansas Veterans Healthcare SystemCentral Arkansas Veterans Healthcare SystemCentral Arkansas Veterans Healthcare SystemRichmond Hill Medical ClinicSt Bernards Medical CenterDiabetes Institute, Ohio UniversityDivision of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesCentral Arkansas Veterans Healthcare SystemDivision of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesDivision of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesDivision of Endocrinology and Metabolism and Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesAbstract Phosphatidylcholine is a ubiquitous phospholipid. It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. The levels of anti-PC IgM increase as the levels of PC-OxPLs increase and, in humans, are inversely correlated with the incidence of cardiovascular diseases and steatohepatitis. PC-OxPLs also decrease bone mass in mice. Overexpression of anti-PC IgM ameliorates atherosclerosis and steatohepatitis, increases bone mass in young mice, and protects against high fat diet- and age-associated osteoporosis. We investigated the relationship between anti-PC IgM plasma levels and bone mineral density (BMD) in a cross-sectional study of 247 participants [mean age: 65.5 (± 8.6) years] without medical conditions known to influence BMD or antibody production. Anti-PC IgM levels negatively correlated with both T- and Z-scores at the lumbar spine, femur and, to a lesser extent, the forearm. These correlations were maintained after adjustment for age, race, and sex. These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis.https://doi.org/10.1038/s41598-025-85624-9Oxidized phospholipidsAnti-PC IgM antibodiesBone mineral density |
| spellingShingle | Michela Palmieri Spyridoula Maraka Horace J. Spencer Jeff D. Thostenson Katherine Dishongh Micheal Knox Betty Ussery Jesse Byrd Jacqueline K. Kuipers Sanaz Abedzadeh-Anaraki Chitharanjan Duvoor Yuanjie Mao Lakshmi Menon James S. Williams Stavros C. Manolagas Robert L. Jilka Elena Ambrogini Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans Scientific Reports Oxidized phospholipids Anti-PC IgM antibodies Bone mineral density |
| title | Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans |
| title_full | Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans |
| title_fullStr | Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans |
| title_full_unstemmed | Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans |
| title_short | Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans |
| title_sort | plasma levels of anti phosphocholine igm antibodies are negatively correlated with bone mineral density in humans |
| topic | Oxidized phospholipids Anti-PC IgM antibodies Bone mineral density |
| url | https://doi.org/10.1038/s41598-025-85624-9 |
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