Cord blood-derived iNK T cells as a platform for allogeneic CAR T cell therapy

Cord blood-derived iNK T cells as a platform for allogeneic CAR T cell therapy

CD1d-restricted invariant Natural Killer (iNK) T cells are a suitable candidate for allogeneic Chimeric Antigen Receptor (CAR) T cell therapy as they do not cause graft-versus-host disease (GvHD) due to the monomorphic nature of CD1d proteins. However, the phenotypic and functional heterogeneity of...

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Bibliographic Details
Main Authors: Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Dan Li, Qing Ma, Elizabeth J. Shpall, Jeffrey J. Molldrem, Jin S. Im
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
invariant natural killer t cells
cord blood
chimeric antigen receptor
acute myeloid leukemia
CAR T cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1621260/full
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