Guarana, Selenium, and L-Carnitine Supplementation Improves the Oxidative Profile but Fails to Reduce Tissue Damage in Rats with Osteoarthritis

Guarana, Selenium, and L-Carnitine Supplementation Improves the Oxidative Profile but Fails to Reduce Tissue Damage in Rats with Osteoarthritis

Osteoarthritis (OA) is a progressive joint disease that is commonly managed with palliative drugs, many of which are associated with undesirable side effects. This study investigated the therapeutic potential of a novel supplementation with guarana, selenium, and L-carnitine (GSC) in a rat model of...

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Main Authors: Aline Zuanazzi Pasinato, José Eduardo Vargas, Julia Spanhol da Silva, Joana Grandó Moretto, Cibele Ferreira Teixeira, Verônica Farina Azzolin, Ivana Beatrice Mânica da Cruz, Camile da Rosa Trevisan, Emanuele Cristina Zub, Renato Puga, Verónica Inés Vargas, Grethel León-Mejía, Rômulo Pillon Barcelos
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
osteoarthritis
inflammation
oxidative stress
nutritional supplement
natural compounds
Online Access:https://www.mdpi.com/2076-3921/14/7/881
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