Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy
We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget’s disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/401362 |
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| author | S. Wakabayashi Y. Togawa K. Yoneyama K. Suehiro N. Kambe H. Matsue |
| author_facet | S. Wakabayashi Y. Togawa K. Yoneyama K. Suehiro N. Kambe H. Matsue |
| author_sort | S. Wakabayashi |
| collection | DOAJ |
| description | We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget’s disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete response was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion, but had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic response, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease. |
| format | Article |
| id | doaj-art-0dab494c18774af8b3e5f607f136ca50 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-0dab494c18774af8b3e5f607f136ca502025-08-20T03:54:24ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712012-01-01201210.1155/2012/401362401362Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab MonotherapyS. Wakabayashi0Y. Togawa1K. Yoneyama2K. Suehiro3N. Kambe4H. Matsue5Department of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Dermatology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanWe report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget’s disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete response was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion, but had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic response, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.http://dx.doi.org/10.1155/2012/401362 |
| spellingShingle | S. Wakabayashi Y. Togawa K. Yoneyama K. Suehiro N. Kambe H. Matsue Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy Case Reports in Dermatological Medicine |
| title | Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy |
| title_full | Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy |
| title_fullStr | Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy |
| title_full_unstemmed | Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy |
| title_short | Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy |
| title_sort | dramatic clinical response of relapsed metastatic extramammary paget s disease to trastuzumab monotherapy |
| url | http://dx.doi.org/10.1155/2012/401362 |
| work_keys_str_mv | AT swakabayashi dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy AT ytogawa dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy AT kyoneyama dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy AT ksuehiro dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy AT nkambe dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy AT hmatsue dramaticclinicalresponseofrelapsedmetastaticextramammarypagetsdiseasetotrastuzumabmonotherapy |