A randomized trial of low-dose thrombolysis, ultrasound-assisted thrombolysis, or heparin for intermediate-high risk pulmonary embolism—the STRATIFY trial: design and statistical analysis plan

A randomized trial of low-dose thrombolysis, ultrasound-assisted thrombolysis, or heparin for intermediate-high risk pulmonary embolism—the STRATIFY trial: design and statistical analysis plan

Abstract Background Intermediate-high risk pulmonary embolism (PE) carries a significant risk of hemodynamic deterioration or death. Treatment should balance efficacy in reducing clot burden with the risk of complications, particularly bleeding. Previous studies on high-dose, short-term thrombolysis...

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Main Authors: Jesper Kjærgaard, Jørn Carlsen, Emilie Sonne-Holm, Sebastian Wiberg, Lene Holmvang, Jens Flensted Lassen, Rikke Sørensen, Dan Høfsten, Peter Sommer Ulriksen, Samir Jawad, Pernille Palm, Jens Jakob Thune, Christian Hassager, Ole P. Kristiansen, Kristian Eskesen, Søren Fanø, Lia E. Bang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Trials
Subjects:
Pulmonary embolism
Intermediate-high risk
Low-dose thrombolysis
Ultrasound-assisted thrombolysis
Clot burden
Online Access:https://doi.org/10.1186/s13063-024-08688-4
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