Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA
In this study, novel amphiphilic fluorescent copolymers poly(N-vinylpyrrolidone)-b-poly(N-methacryloyl-N'-(α-naphthyl)thiourea) (PVP-b-PNT) were synthesized via ATRP with poly(N-vinylpyrrolidone)-Cl as macroinitiator and N-methacryloyl-N'-α-naphthylthiourea (NT) as hydrop...
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| Format: | Article |
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| Language: | English |
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Budapest University of Technology and Economics
2007-06-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0000243&mi=cd |
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| collection | DOAJ |
| description | In this study, novel amphiphilic fluorescent copolymers poly(N-vinylpyrrolidone)-b-poly(N-methacryloyl-N'-(α-naphthyl)thiourea) (PVP-b-PNT) were synthesized via ATRP with poly(N-vinylpyrrolidone)-Cl as macroinitiator and N-methacryloyl-N'-α-naphthylthiourea (NT) as hydrophobic segment. PVP-b-PNT copolymers were characterized by 1H NMR, GPC-MALLS and fluorescence measurements. The aggregation behavior of PVP-b-PNT in water was investigated by transmission electron microscope (TEM) and dynamic light scattering (DLS) measurement. The photophysics behavior of PVP-b-PNT showed that block copolymer formed strong excimer. The interaction of DNA with the block copolymer made the excimer of block copolymer quench. The cytotoxicity result of PVP-b-PNT in cell culture in vitro indicated that this copolymer PVP-b-PNT had good biocompatibility. |
| format | Article |
| id | doaj-art-0da26e5ae6574483bd3d343b630382fd |
| institution | DOAJ |
| issn | 1788-618X |
| language | English |
| publishDate | 2007-06-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-0da26e5ae6574483bd3d343b630382fd2025-08-20T03:15:53ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2007-06-011635636310.3144/expresspolymlett.2007.50Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNAIn this study, novel amphiphilic fluorescent copolymers poly(N-vinylpyrrolidone)-b-poly(N-methacryloyl-N'-(α-naphthyl)thiourea) (PVP-b-PNT) were synthesized via ATRP with poly(N-vinylpyrrolidone)-Cl as macroinitiator and N-methacryloyl-N'-α-naphthylthiourea (NT) as hydrophobic segment. PVP-b-PNT copolymers were characterized by 1H NMR, GPC-MALLS and fluorescence measurements. The aggregation behavior of PVP-b-PNT in water was investigated by transmission electron microscope (TEM) and dynamic light scattering (DLS) measurement. The photophysics behavior of PVP-b-PNT showed that block copolymer formed strong excimer. The interaction of DNA with the block copolymer made the excimer of block copolymer quench. The cytotoxicity result of PVP-b-PNT in cell culture in vitro indicated that this copolymer PVP-b-PNT had good biocompatibility.http://www.expresspolymlett.com/letolt.php?file=EPL-0000243&mi=cdBiocompatible polymersblockfluorescenceexcimer |
| spellingShingle | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA eXPRESS Polymer Letters Biocompatible polymers block fluorescence excimer |
| title | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA |
| title_full | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA |
| title_fullStr | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA |
| title_full_unstemmed | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA |
| title_short | Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA |
| title_sort | novel fluorescent amphiphilic block copolymers photophysics behavior and interactions with dna |
| topic | Biocompatible polymers block fluorescence excimer |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0000243&mi=cd |