A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease

A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer’s disease

Previous studies identified atrophy-based Alzheimer's disease(AD) subtypes linked to distinct clinical symptoms, but their consistency across subtyping approaches remains unclear. This large-scale study evaluates subtype concordance using two data-driven approaches. In this work, we analyzed da...

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Main Authors: Vikram Venkatraghavan, Damiano Archetti, Pierrick Bourgeat, Chenyang Jiang, Mara ten Kate, Anna C. van Loenhoud, Rik Ossenkoppele, Charlotte E. Teunissen, Elsmarieke van de Giessen, Yolande A.L. Pijnenburg, Giovanni B. Frisoni, Béla Weiss, Zoltán Vidnyánszky, Tibor Auer, Stanley Durrleman, Alberto Redolfi, Simon M. Laws, Paul Maruff, Neil P. Oxtoby, Andre Altmann, Daniel C. Alexander, Wiesje M. van der Flier, Frederik Barkhof, Betty M. Tijms
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:NeuroImage
Subjects:
Alzheimer’s disease
Heterogeneity
Subtypes
Data-driven
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811925003842
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