Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR‐Cas12a

Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR‐Cas12a

Abstract CRISPR‐Cas12a works like a sophisticated algorithm in nucleic acid detection, yet its challenge lies in sometimes failing to distinguish targets with mismatches due to its specificity limitations. Here, the mismatch profiles, including the quantity, location, and type of mismatches in the C...

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Bibliographic Details
Main Authors: Xin Guan, Rui Yang, Jiongyu Zhang, Jeong Moon, Chengyu Hou, Chong Guo, Lori Avery, Danielle Scarola, Daniel S. Roberts, Rocco LaSala, Changchun Liu
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
approximate pattern matching
CRISPR‐Cas12a
HR‐HPV detection
paper‐based microfluidic chip
precise querying
Online Access:https://doi.org/10.1002/advs.202411021
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https://doi.org/10.1002/advs.202411021

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