Features of liver structural organization in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a severe psychological condition resulting from traumatic experiences, leading to long-term physiological changes in the body. It affects mental health and induces hormonal imbalances that disrupt the hypothalamus-pituitary-adrenal axis, influencing multiple...
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Kazimierz Wielki University
2024-10-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/55689 |
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| author | Sofiia Chorniy Olga Denefil Viktoriia Miroshnyk |
| author_facet | Sofiia Chorniy Olga Denefil Viktoriia Miroshnyk |
| author_sort | Sofiia Chorniy |
| collection | DOAJ |
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Posttraumatic stress disorder (PTSD) is a severe psychological condition resulting from traumatic experiences, leading to long-term physiological changes in the body. It affects mental health and induces hormonal imbalances that disrupt the hypothalamus-pituitary-adrenal axis, influencing multiple organ systems. While PTSD is often linked with comorbid conditions like depression and anxiety, its effects on the hepatobiliary system are less understood.
Aim. This study aimed to assess PTSD's impact on liver morphology in rats of different sexes and compare the severity of changes between males and females, contributing to the understanding of stress-related physiological effects.
Materials and Methods. The experiment involved 40 Wistar rats, divided into control and PTSD-induced groups for both sexes. A validated stress induction protocol was used, followed by a thorough morphological analysis of liver specimens fixed in 10% formalin and stained with hematoxylin-eosin. Histopathological evaluation focused on liver architecture, hepatocyte condition, vascular integrity, and cellular organization.
Results. Control animals displayed standard liver structure, while PTSD-induced groups exhibited significant morphological changes, such as dystrophic alterations in hepatocytes, congestion in hepatic veins, and the formation of blood clots. Female rats showed more pronounced changes than males, including hepatocyte swelling and vacuolization, indicating heightened cellular stress and reduced regenerative capacity.
Conclusions. The findings highlight that PTSD-related liver changes were more significant in female rats, emphasizing the importance of considering gender differences in stress-related disorders. These alterations suggest a complex interaction between chronic psychological stress and liver physiology, warranting further research on mechanisms by which PTSD affects the hepatobiliary system and potential therapeutic interventions. for at-risk populations.
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| format | Article |
| id | doaj-art-0d8b8b4d532a4ec5b18d198c809087f8 |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-0d8b8b4d532a4ec5b18d198c809087f82025-08-20T02:10:53ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-10-017010.12775/JEHS.2024.70.55689Features of liver structural organization in posttraumatic stress disorderSofiia Chorniy0Olga Denefil1Viktoriia Miroshnyk 2I.Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical UniversityI.Horbachevsky Ternopil National Medical University Posttraumatic stress disorder (PTSD) is a severe psychological condition resulting from traumatic experiences, leading to long-term physiological changes in the body. It affects mental health and induces hormonal imbalances that disrupt the hypothalamus-pituitary-adrenal axis, influencing multiple organ systems. While PTSD is often linked with comorbid conditions like depression and anxiety, its effects on the hepatobiliary system are less understood. Aim. This study aimed to assess PTSD's impact on liver morphology in rats of different sexes and compare the severity of changes between males and females, contributing to the understanding of stress-related physiological effects. Materials and Methods. The experiment involved 40 Wistar rats, divided into control and PTSD-induced groups for both sexes. A validated stress induction protocol was used, followed by a thorough morphological analysis of liver specimens fixed in 10% formalin and stained with hematoxylin-eosin. Histopathological evaluation focused on liver architecture, hepatocyte condition, vascular integrity, and cellular organization. Results. Control animals displayed standard liver structure, while PTSD-induced groups exhibited significant morphological changes, such as dystrophic alterations in hepatocytes, congestion in hepatic veins, and the formation of blood clots. Female rats showed more pronounced changes than males, including hepatocyte swelling and vacuolization, indicating heightened cellular stress and reduced regenerative capacity. Conclusions. The findings highlight that PTSD-related liver changes were more significant in female rats, emphasizing the importance of considering gender differences in stress-related disorders. These alterations suggest a complex interaction between chronic psychological stress and liver physiology, warranting further research on mechanisms by which PTSD affects the hepatobiliary system and potential therapeutic interventions. for at-risk populations. https://apcz.umk.pl/JEHS/article/view/55689posttraumatic stress disordermorphological changeshepatocytesdystrophyhepatobiliary systemstress |
| spellingShingle | Sofiia Chorniy Olga Denefil Viktoriia Miroshnyk Features of liver structural organization in posttraumatic stress disorder Journal of Education, Health and Sport posttraumatic stress disorder morphological changes hepatocytes dystrophy hepatobiliary system stress |
| title | Features of liver structural organization in posttraumatic stress disorder |
| title_full | Features of liver structural organization in posttraumatic stress disorder |
| title_fullStr | Features of liver structural organization in posttraumatic stress disorder |
| title_full_unstemmed | Features of liver structural organization in posttraumatic stress disorder |
| title_short | Features of liver structural organization in posttraumatic stress disorder |
| title_sort | features of liver structural organization in posttraumatic stress disorder |
| topic | posttraumatic stress disorder morphological changes hepatocytes dystrophy hepatobiliary system stress |
| url | https://apcz.umk.pl/JEHS/article/view/55689 |
| work_keys_str_mv | AT sofiiachorniy featuresofliverstructuralorganizationinposttraumaticstressdisorder AT olgadenefil featuresofliverstructuralorganizationinposttraumaticstressdisorder AT viktoriiamiroshnyk featuresofliverstructuralorganizationinposttraumaticstressdisorder |