Inhibition of SOD1 trimerization is a novel drug target for ALS disease

Inhibition of SOD1 trimerization is a novel drug target for ALS disease

Abstract Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that begins with motor neuron death in the spinal cord and cerebral cortex, ultimately resulting in death from respiratory distress (breathing failure). About 90% of ALS cases are sporadic, and 10% of...

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Main Authors: Tae-Gyun Woo, Jin Han, Yuju Kim, Young jun Hwang, Mua Lee, So-mi Kang, Soyoung Park, Yeongseon Ji, Yeon-Ho Chung, Songyoung Baek, Eunbyeol Shin, Minju-Kim, Hyewon Jang, Yun-Jeong Shin, Yonghoon Kwon, Bae-Hoon Kim, Bum-Joon Park
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Translational Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis disease
SOD1 aggregation
SOD1 trimer
Neurodegeneration
Non-clinical study
Online Access:https://doi.org/10.1186/s40035-025-00483-8
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