Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures

IntroductionKetogenic diet (KD), a high-fat, low-carbohydrate, and adequate protein diet, is a non-pharmacological treatment for refractory epilepsy. However, their mechanism of action is not fully understood. The cation-chloride cotransporter, KCC2, transports chloride out of neurons, thus contribu...

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Main Authors: Leticia Granados-Rojas, Leonardo Hernández-López, Emmanuel Leonardo Bahena-Alvarez, Tarsila Elizabeth Juárez-Zepeda, Verónica Custodio, Joyce Graciela Martínez-Galindo, Karina Jerónimo-Cruz, Miguel Tapia-Rodríguez, America Vanoye-Carlo, Pilar Duran, Carmen Rubio
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neuroscience
Subjects:
ketogenic diet
kindling
KCC2
dentate gyrus
CA3
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1489407/full
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