Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0
Objective: To determine the bonding strength of 2-Octyl cyanoacrylate (Dermabond) compared with N-Butyl-2-cyanoacrylate (Histoacryl) and nylon 10-0 (Alcon,) in sealing experimentally induced corneal perforations in cadaver porcine eyes. Methods: This is a single-blind, randomized, physical experi...
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Philippine Academy of Ophthalmology
2005-03-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/423 |
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| author | Jocelyn R. Elises, MD Leo DP Cubillan, MD |
| author_facet | Jocelyn R. Elises, MD Leo DP Cubillan, MD |
| author_sort | Jocelyn R. Elises, MD |
| collection | DOAJ |
| description | Objective: To determine the bonding strength of 2-Octyl cyanoacrylate (Dermabond) compared with N-Butyl-2-cyanoacrylate (Histoacryl) and nylon 10-0 (Alcon,) in sealing experimentally induced corneal perforations in cadaver porcine eyes.
Methods: This is a single-blind, randomized, physical experimental study involving 78 freshly enucleated porcine eyes in which perforations of 3.0 and 5.1 mm were made in the cornea and randomly sealed with either interrupted nylon 10-0 (n=13), Dermabond (n=13), or Histoacryl (n=13). Intraocular pressures were raised by injecting normal saline into the anterior chamber and postsealing leaking pressures were measured using a precalibrated manometer attached to the anterior chamber maintainer. Fisher’s Exact Test was used to determine the difference in proportion of eyes that leaked, and Wilcoxon signed ranked test to compare the mean leaking pressures.
Results: In the 3.0 mm group, the proportion of eyes that leaked in Dermabond (2/13, 15.4%) and Histoacryl (1/13, 7.7%) were comparable (p = 1.00). Proportion of leak in nylon 10-0 (13/13, 100%) was significantly higher (p < 0.001). Mean leaking pressures of Dermabond (79.5 mm Hg) and Histoacryl (88.0 mm Hg) were higher compared with that of nylon 10-0 (61.44 mm Hg) (p < 0.05). In the 5.1 mm group, proportion of eyes that leaked in Dermabond (4/13, 30.8%) and Histoacryl (2/13, 15.4%) were comparable (p = 0.65). Proportion of leak in nylon 10-0 (13/13, 100%) was significantly higher (p < 0.001). Mean leaking pressures of Dermabond (92.75 mm Hg) and Histoacryl (86.5 mm Hg) were higher than that of nylon 10-0 (59.08 mm Hg) (p = 0.07 and p = 0.10).
Conclusion: The bonding strengths of Dermabond and Histoacryl are comparable and greater than that of nylon 10-0. Both are effective for 3.0 mm and 5.1 mm corneal perforations. |
| format | Article |
| id | doaj-art-0d7813ff3dcd4d02b425989dda4bfc31 |
| institution | OA Journals |
| issn | 0031-7659 |
| language | English |
| publishDate | 2005-03-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-0d7813ff3dcd4d02b425989dda4bfc312025-08-20T01:49:47ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592005-03-013012023423Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0Jocelyn R. Elises, MD0Leo DP Cubillan, MD1Department of Ophthalmology and Visual Sciences University of the Philippines-Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences University of the Philippines-Philippine General Hospital Manila, Philippines; Institute of Ophthalmology University of the Philippines Manila Manila, PhilippinesObjective: To determine the bonding strength of 2-Octyl cyanoacrylate (Dermabond) compared with N-Butyl-2-cyanoacrylate (Histoacryl) and nylon 10-0 (Alcon,) in sealing experimentally induced corneal perforations in cadaver porcine eyes. Methods: This is a single-blind, randomized, physical experimental study involving 78 freshly enucleated porcine eyes in which perforations of 3.0 and 5.1 mm were made in the cornea and randomly sealed with either interrupted nylon 10-0 (n=13), Dermabond (n=13), or Histoacryl (n=13). Intraocular pressures were raised by injecting normal saline into the anterior chamber and postsealing leaking pressures were measured using a precalibrated manometer attached to the anterior chamber maintainer. Fisher’s Exact Test was used to determine the difference in proportion of eyes that leaked, and Wilcoxon signed ranked test to compare the mean leaking pressures. Results: In the 3.0 mm group, the proportion of eyes that leaked in Dermabond (2/13, 15.4%) and Histoacryl (1/13, 7.7%) were comparable (p = 1.00). Proportion of leak in nylon 10-0 (13/13, 100%) was significantly higher (p < 0.001). Mean leaking pressures of Dermabond (79.5 mm Hg) and Histoacryl (88.0 mm Hg) were higher compared with that of nylon 10-0 (61.44 mm Hg) (p < 0.05). In the 5.1 mm group, proportion of eyes that leaked in Dermabond (4/13, 30.8%) and Histoacryl (2/13, 15.4%) were comparable (p = 0.65). Proportion of leak in nylon 10-0 (13/13, 100%) was significantly higher (p < 0.001). Mean leaking pressures of Dermabond (92.75 mm Hg) and Histoacryl (86.5 mm Hg) were higher than that of nylon 10-0 (59.08 mm Hg) (p = 0.07 and p = 0.10). Conclusion: The bonding strengths of Dermabond and Histoacryl are comparable and greater than that of nylon 10-0. Both are effective for 3.0 mm and 5.1 mm corneal perforations.https://paojournal.com/index.php/pjo/article/view/423corneal perforations2-octyl cyanoacrylaten-butyl-2-cyanoacrylate |
| spellingShingle | Jocelyn R. Elises, MD Leo DP Cubillan, MD Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 Philippine Journal of Ophthalmology corneal perforations 2-octyl cyanoacrylate n-butyl-2-cyanoacrylate |
| title | Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 |
| title_full | Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 |
| title_fullStr | Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 |
| title_full_unstemmed | Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 |
| title_short | Bonding strengths of 2-octyl cyanoacrylate, N-butyl-2- cyanoacrylate, and nylon 10-0 |
| title_sort | bonding strengths of 2 octyl cyanoacrylate n butyl 2 cyanoacrylate and nylon 10 0 |
| topic | corneal perforations 2-octyl cyanoacrylate n-butyl-2-cyanoacrylate |
| url | https://paojournal.com/index.php/pjo/article/view/423 |
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