The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes
OBJECTIVE: To evaluate maternal Resolvin D1 levels in women with gestational diabetes mellitus (GDM) and investigate the association between perinatal outcomes. STUDY DESIGN: This case-control study included 88 singleton pregnancies, conducted from August 2023 to January 2024, at a tertiary care...
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| Format: | Article |
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Medical Network
2024-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1505 |
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| author | Zeynep Seyhanli Burak Bayraktar Mevlut Bucak Gulsan Karabay Betul Tokgoz Cakir Can Ozan Ulusoy Gizem Aktemur Selver Ozge Sefik Serap Topkara Sucu Sevki Celen Ali Turhan Caglar |
| author_facet | Zeynep Seyhanli Burak Bayraktar Mevlut Bucak Gulsan Karabay Betul Tokgoz Cakir Can Ozan Ulusoy Gizem Aktemur Selver Ozge Sefik Serap Topkara Sucu Sevki Celen Ali Turhan Caglar |
| author_sort | Zeynep Seyhanli |
| collection | DOAJ |
| description |
OBJECTIVE: To evaluate maternal Resolvin D1 levels in women with gestational diabetes mellitus (GDM) and investigate the association between perinatal outcomes.
STUDY DESIGN: This case-control study included 88 singleton pregnancies, conducted from August 2023 to January 2024, at a tertiary care center. Participants were divided into two groups: 44 pregnant women diagnosed with GDM comprised the study group, and 44 healthy pregnant women served as the control group. Additionally, the GDM group was categorized based on management approach into 21 women managed with diet alone and 23 women requiring insulin therapy. Maternal plasma Resolvin D1 levels and maternal-neonatal outcomes were then compared between groups. The analysis involved determining the optimal Resolvin D1 cut-off levels for predicting composite adverse neonatal outcomes in GDM using receiver operating characteristic curve (ROC) analysis.
RESULTS: The plasma Resolvin D1 level in pregnant women with GDM was significantly higher compared to the control group (337±74.1 vs. 297±56.7, p<0.001). Furthermore, maternal plasma Resolvin D1 levels were associated with composite adverse neonatal outcomes [presence of at least one of the following conditions: preterm birth (<37 weeks), low birth weight (LBW) (<2500 grams), neonatal hypoglycemia, hyperbilirubinemia, APGAR score at 5th minute <7, respiratory distress syndrome (RDS), and admission to the neonatal intensive care unit (NICU)], with a cut-off of >338.75, showing a sensitivity of 56.3%, a specificity of 79.2%, and an AUC of 0.675 (95% CI: 0.567-0.771, p=0.024).
CONCLUSIONS: This study demonstrated that pregnancies affected by GDM exhibit elevated levels of Resolvin D1, which is associated with a higher incidence of composite adverse neonatal outcomes.
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| format | Article |
| id | doaj-art-0d77b6a7aa20451d885c365c04e9701d |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-0d77b6a7aa20451d885c365c04e9701d2025-02-11T21:18:37ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182024-08-0130210.21613/GORM.2023.1505The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal OutcomesZeynep Seyhanli0Burak Bayraktar1Mevlut Bucak2Gulsan Karabay3Betul Tokgoz Cakir4Can Ozan Ulusoy5Gizem Aktemur6Selver Ozge Sefik7Serap Topkara Sucu8Sevki Celen9Ali Turhan Caglar10Ankara Etlik City HospitalDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /TurkiyeDepartment of Perinatology, Ankara Etlik City Hospital, Ankara /Turkiye OBJECTIVE: To evaluate maternal Resolvin D1 levels in women with gestational diabetes mellitus (GDM) and investigate the association between perinatal outcomes. STUDY DESIGN: This case-control study included 88 singleton pregnancies, conducted from August 2023 to January 2024, at a tertiary care center. Participants were divided into two groups: 44 pregnant women diagnosed with GDM comprised the study group, and 44 healthy pregnant women served as the control group. Additionally, the GDM group was categorized based on management approach into 21 women managed with diet alone and 23 women requiring insulin therapy. Maternal plasma Resolvin D1 levels and maternal-neonatal outcomes were then compared between groups. The analysis involved determining the optimal Resolvin D1 cut-off levels for predicting composite adverse neonatal outcomes in GDM using receiver operating characteristic curve (ROC) analysis. RESULTS: The plasma Resolvin D1 level in pregnant women with GDM was significantly higher compared to the control group (337±74.1 vs. 297±56.7, p<0.001). Furthermore, maternal plasma Resolvin D1 levels were associated with composite adverse neonatal outcomes [presence of at least one of the following conditions: preterm birth (<37 weeks), low birth weight (LBW) (<2500 grams), neonatal hypoglycemia, hyperbilirubinemia, APGAR score at 5th minute <7, respiratory distress syndrome (RDS), and admission to the neonatal intensive care unit (NICU)], with a cut-off of >338.75, showing a sensitivity of 56.3%, a specificity of 79.2%, and an AUC of 0.675 (95% CI: 0.567-0.771, p=0.024). CONCLUSIONS: This study demonstrated that pregnancies affected by GDM exhibit elevated levels of Resolvin D1, which is associated with a higher incidence of composite adverse neonatal outcomes. https://gorm.com.tr/index.php/GORM/article/view/1505Resolvin D1gestational diabetes mellitusperinatal outcomes |
| spellingShingle | Zeynep Seyhanli Burak Bayraktar Mevlut Bucak Gulsan Karabay Betul Tokgoz Cakir Can Ozan Ulusoy Gizem Aktemur Selver Ozge Sefik Serap Topkara Sucu Sevki Celen Ali Turhan Caglar The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes Gynecology Obstetrics & Reproductive Medicine Resolvin D1 gestational diabetes mellitus perinatal outcomes |
| title | The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes |
| title_full | The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes |
| title_fullStr | The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes |
| title_full_unstemmed | The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes |
| title_short | The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes |
| title_sort | association between resolvin d1 levels and gestational diabetes mellitus implications for perinatal outcomes |
| topic | Resolvin D1 gestational diabetes mellitus perinatal outcomes |
| url | https://gorm.com.tr/index.php/GORM/article/view/1505 |
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