Preoperative embolization of head and neck tumors: a systematic review and meta-analysis
Abstract Purpose Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis. Methods A comprehensive search was co...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-025-03901-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849329522842796032 |
|---|---|
| author | Zhen Long Yu-Hui Su Jing-Bin Zhu Qi-Sen Yao Zhen Feng Peng-Yu Chen Yuan-Feng Liang Fu Zhu Yu Ning |
| author_facet | Zhen Long Yu-Hui Su Jing-Bin Zhu Qi-Sen Yao Zhen Feng Peng-Yu Chen Yuan-Feng Liang Fu Zhu Yu Ning |
| author_sort | Zhen Long |
| collection | DOAJ |
| description | Abstract Purpose Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis. Methods A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane databases to identify relevant literature on preoperative embolization for head and neck tumors up to March 2025. Randomized controlled trials, cohort studies, and case-control studies involving embolization and non-embolization groups were included. Eligible studies were selected for meta-analysis to estimate intraoperative blood loss, operative time, and postoperative complications. Data were analyzed using Review Manager 5.4 software. Results A total of 30 studies met the inclusion criteria, including 7 randomized controlled trials and 23 cohort studies, encompassing a total of 1,039 patients. Preoperative embolization reduced estimated blood loss. The estimated blood loss was 456 ml in the embolization group compared to 516 ml in the non-embolization group (Standard Mean Difference = -0.67; 95% CI: -1.02 to -0.32; P = 0.0002). Preoperative embolization was associated with increased surgical resection time. The mean resection time was 312 min in the embolization group and 305 min in the non-embolization group (Standard Mean Difference = -0.66; 95% CI: -1.21 to -0.12; P = 0.02). Preoperative embolization did not reduce postoperative complications (Odd ratio = 1.06; 95% CI: 0.42, 2.70; P = 0.90). Conclusions Compared with surgery without preoperative embolization for head and neck tumors, preoperative embolization appears to reduce intraoperative estimated blood loss and increase surgical resection time; however, it does not significantly reduce incidence of complications. |
| format | Article |
| id | doaj-art-0d777028df5d4e2cafe2f6f88cf72834 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-0d777028df5d4e2cafe2f6f88cf728342025-08-20T03:47:14ZengBMCWorld Journal of Surgical Oncology1477-78192025-06-0123111010.1186/s12957-025-03901-3Preoperative embolization of head and neck tumors: a systematic review and meta-analysisZhen Long0Yu-Hui Su1Jing-Bin Zhu2Qi-Sen Yao3Zhen Feng4Peng-Yu Chen5Yuan-Feng Liang6Fu Zhu7Yu Ning8Department of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Otorhinolaryngology, the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinDepartment of Vascular and Endovascular Surgery, the First People’s Hospital of YulinAbstract Purpose Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis. Methods A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane databases to identify relevant literature on preoperative embolization for head and neck tumors up to March 2025. Randomized controlled trials, cohort studies, and case-control studies involving embolization and non-embolization groups were included. Eligible studies were selected for meta-analysis to estimate intraoperative blood loss, operative time, and postoperative complications. Data were analyzed using Review Manager 5.4 software. Results A total of 30 studies met the inclusion criteria, including 7 randomized controlled trials and 23 cohort studies, encompassing a total of 1,039 patients. Preoperative embolization reduced estimated blood loss. The estimated blood loss was 456 ml in the embolization group compared to 516 ml in the non-embolization group (Standard Mean Difference = -0.67; 95% CI: -1.02 to -0.32; P = 0.0002). Preoperative embolization was associated with increased surgical resection time. The mean resection time was 312 min in the embolization group and 305 min in the non-embolization group (Standard Mean Difference = -0.66; 95% CI: -1.21 to -0.12; P = 0.02). Preoperative embolization did not reduce postoperative complications (Odd ratio = 1.06; 95% CI: 0.42, 2.70; P = 0.90). Conclusions Compared with surgery without preoperative embolization for head and neck tumors, preoperative embolization appears to reduce intraoperative estimated blood loss and increase surgical resection time; however, it does not significantly reduce incidence of complications.https://doi.org/10.1186/s12957-025-03901-3EmbolizationHead and neck tumorsVascular surgeryOtolaryngologySystematic reviewMeta-Analysis |
| spellingShingle | Zhen Long Yu-Hui Su Jing-Bin Zhu Qi-Sen Yao Zhen Feng Peng-Yu Chen Yuan-Feng Liang Fu Zhu Yu Ning Preoperative embolization of head and neck tumors: a systematic review and meta-analysis World Journal of Surgical Oncology Embolization Head and neck tumors Vascular surgery Otolaryngology Systematic review Meta-Analysis |
| title | Preoperative embolization of head and neck tumors: a systematic review and meta-analysis |
| title_full | Preoperative embolization of head and neck tumors: a systematic review and meta-analysis |
| title_fullStr | Preoperative embolization of head and neck tumors: a systematic review and meta-analysis |
| title_full_unstemmed | Preoperative embolization of head and neck tumors: a systematic review and meta-analysis |
| title_short | Preoperative embolization of head and neck tumors: a systematic review and meta-analysis |
| title_sort | preoperative embolization of head and neck tumors a systematic review and meta analysis |
| topic | Embolization Head and neck tumors Vascular surgery Otolaryngology Systematic review Meta-Analysis |
| url | https://doi.org/10.1186/s12957-025-03901-3 |
| work_keys_str_mv | AT zhenlong preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT yuhuisu preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT jingbinzhu preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT qisenyao preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT zhenfeng preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT pengyuchen preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT yuanfengliang preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT fuzhu preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis AT yuning preoperativeembolizationofheadandnecktumorsasystematicreviewandmetaanalysis |