Nilotinib-Associated Destructive Thyroiditis
Protein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia. Tyrosine kinases are enzymes expressed in multiple tissues and are involved in several si...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/736092 |
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| _version_ | 1850233018876166144 |
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| author | Suhalia Bakerywala Monica D. Schwarcz Michael D. Goldberg Guy Valiquette Irene A. Weiss |
| author_facet | Suhalia Bakerywala Monica D. Schwarcz Michael D. Goldberg Guy Valiquette Irene A. Weiss |
| author_sort | Suhalia Bakerywala |
| collection | DOAJ |
| description | Protein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia. Tyrosine kinases are enzymes expressed in multiple tissues and are involved in several signaling pathways influencing cellular growth. Below we describe a patient who developed an unusual complication of tyrosine kinase inhibitor therapy: thyrotoxicosis due to destructive thyroiditis. We review the pathophysiology of tyrosine kinase inhibitor-induced thyroid dysfunction particularly with regard to new second-generation tyrosine kinase inhibitors. |
| format | Article |
| id | doaj-art-0d759ccd81ff4cd9aaf21ae48214498a |
| institution | OA Journals |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-0d759ccd81ff4cd9aaf21ae48214498a2025-08-20T02:03:00ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/736092736092Nilotinib-Associated Destructive ThyroiditisSuhalia Bakerywala0Monica D. Schwarcz1Michael D. Goldberg2Guy Valiquette3Irene A. Weiss4Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USADivision of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USADivision of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USADivision of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USADivision of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USAProtein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia. Tyrosine kinases are enzymes expressed in multiple tissues and are involved in several signaling pathways influencing cellular growth. Below we describe a patient who developed an unusual complication of tyrosine kinase inhibitor therapy: thyrotoxicosis due to destructive thyroiditis. We review the pathophysiology of tyrosine kinase inhibitor-induced thyroid dysfunction particularly with regard to new second-generation tyrosine kinase inhibitors.http://dx.doi.org/10.1155/2015/736092 |
| spellingShingle | Suhalia Bakerywala Monica D. Schwarcz Michael D. Goldberg Guy Valiquette Irene A. Weiss Nilotinib-Associated Destructive Thyroiditis Case Reports in Endocrinology |
| title | Nilotinib-Associated Destructive Thyroiditis |
| title_full | Nilotinib-Associated Destructive Thyroiditis |
| title_fullStr | Nilotinib-Associated Destructive Thyroiditis |
| title_full_unstemmed | Nilotinib-Associated Destructive Thyroiditis |
| title_short | Nilotinib-Associated Destructive Thyroiditis |
| title_sort | nilotinib associated destructive thyroiditis |
| url | http://dx.doi.org/10.1155/2015/736092 |
| work_keys_str_mv | AT suhaliabakerywala nilotinibassociateddestructivethyroiditis AT monicadschwarcz nilotinibassociateddestructivethyroiditis AT michaeldgoldberg nilotinibassociateddestructivethyroiditis AT guyvaliquette nilotinibassociateddestructivethyroiditis AT ireneaweiss nilotinibassociateddestructivethyroiditis |