Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo.
Post-transcriptional mRNA regulation by RNA binding proteins (RBPs) associated with AU-rich elements (AREs) present in the 3' untranslated region (3'UTR) of specific mRNAs modulates transcript stability and translation in eukaryotic cells. Here we have functionally characterised the import...
Saved in:
| Main Authors: | Manuel D Díaz-Muñoz, Sarah E Bell, Martin Turner |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116899&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays
by: Khoa Dao, et al.
Published: (2025-07-01) -
Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos
by: Mengwei Niu, et al.
Published: (2024-11-01) -
UTR-Insight: integrating deep learning for efficient 5′ UTR discovery and design
by: Saichao Pan, et al.
Published: (2025-02-01) -
Evaluation of synthetic mRNA with selected UTR sequences and alternative poly(A) tail, in vitro and in vivo
by: Ayoub Medjmedj, et al.
Published: (2025-09-01) -
Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
by: Nejc Haberman, et al.
Published: (2024-11-01)