Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports
Leydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hy...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2023/7178201 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850233015299473408 |
|---|---|
| author | Margaret Caulkins Jason Ricciuti Mohamed Desouki Katherine LaVigne Mager |
| author_facet | Margaret Caulkins Jason Ricciuti Mohamed Desouki Katherine LaVigne Mager |
| author_sort | Margaret Caulkins |
| collection | DOAJ |
| description | Leydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hyperandrogenism, whose symptoms resolved after bilateral salpingo-oophorectomy (BSO). The second patient presented with postmenopausal bleeding and an abdominal mass. Following total abdominal hysterectomy (TAH) and BSO, pathology showed ovarian LCH with concomitant endometrial cancer. The diagnosis of LCH is complex and requires careful investigation of many differential diagnoses. Incidentally discovered LCH may shed light on evolution and disease progression. Cases of LCH found in the setting of endometrial pathology may have implications on other states of testosterone excess. |
| format | Article |
| id | doaj-art-0d68343759b948eeb38c47cf2f420708 |
| institution | OA Journals |
| issn | 2090-6692 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0d68343759b948eeb38c47cf2f4207082025-08-20T02:03:00ZengWileyCase Reports in Obstetrics and Gynecology2090-66922023-01-01202310.1155/2023/7178201Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case ReportsMargaret Caulkins0Jason Ricciuti1Mohamed Desouki2Katherine LaVigne Mager3Roswell Park Comprehensive Cancer InstituteRoswell Park Comprehensive Cancer InstituteRoswell Park Comprehensive Cancer InstituteRoswell Park Comprehensive Cancer InstituteLeydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hyperandrogenism, whose symptoms resolved after bilateral salpingo-oophorectomy (BSO). The second patient presented with postmenopausal bleeding and an abdominal mass. Following total abdominal hysterectomy (TAH) and BSO, pathology showed ovarian LCH with concomitant endometrial cancer. The diagnosis of LCH is complex and requires careful investigation of many differential diagnoses. Incidentally discovered LCH may shed light on evolution and disease progression. Cases of LCH found in the setting of endometrial pathology may have implications on other states of testosterone excess.http://dx.doi.org/10.1155/2023/7178201 |
| spellingShingle | Margaret Caulkins Jason Ricciuti Mohamed Desouki Katherine LaVigne Mager Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports Case Reports in Obstetrics and Gynecology |
| title | Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports |
| title_full | Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports |
| title_fullStr | Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports |
| title_full_unstemmed | Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports |
| title_short | Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports |
| title_sort | varying phenotypes of leydig cell hyperplasia of the ovary two case reports |
| url | http://dx.doi.org/10.1155/2023/7178201 |
| work_keys_str_mv | AT margaretcaulkins varyingphenotypesofleydigcellhyperplasiaoftheovarytwocasereports AT jasonricciuti varyingphenotypesofleydigcellhyperplasiaoftheovarytwocasereports AT mohameddesouki varyingphenotypesofleydigcellhyperplasiaoftheovarytwocasereports AT katherinelavignemager varyingphenotypesofleydigcellhyperplasiaoftheovarytwocasereports |