PPARγ in Inflammatory Bowel Disease
Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors. The colon is a major tissue which expresses PPARγ in epithelial cells and, to a lesser degree, in macrophages and lymphocy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/620839 |
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| _version_ | 1832551163611840512 |
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| author | Vito Annese Francesca Rogai Alessia Settesoldi Siro Bagnoli |
| author_facet | Vito Annese Francesca Rogai Alessia Settesoldi Siro Bagnoli |
| author_sort | Vito Annese |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors. The colon is a major tissue which expresses PPARγ in epithelial cells and, to a lesser degree, in macrophages and lymphocytes and plays a role in the regulation of intestinal inflammation. Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). This paper will specifically focus on potential role of PPARγ in the predisposition and physiopathology of IBD and will analyze its possible role in medical therapy. |
| format | Article |
| id | doaj-art-0d67114328a84dec95f4fcd8601126d2 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-0d67114328a84dec95f4fcd8601126d22025-02-03T06:04:48ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/620839620839PPARγ in Inflammatory Bowel DiseaseVito Annese0Francesca Rogai1Alessia Settesoldi2Siro Bagnoli3Gastroenterology Unit, Careggi, University Hospital, 50134 Florence, ItalyGastroenterology Unit, Careggi, University Hospital, 50134 Florence, ItalyGastroenterology Unit, Careggi, University Hospital, 50134 Florence, ItalyGastroenterology Unit, Careggi, University Hospital, 50134 Florence, ItalyPeroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors. The colon is a major tissue which expresses PPARγ in epithelial cells and, to a lesser degree, in macrophages and lymphocytes and plays a role in the regulation of intestinal inflammation. Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). This paper will specifically focus on potential role of PPARγ in the predisposition and physiopathology of IBD and will analyze its possible role in medical therapy.http://dx.doi.org/10.1155/2012/620839 |
| spellingShingle | Vito Annese Francesca Rogai Alessia Settesoldi Siro Bagnoli PPARγ in Inflammatory Bowel Disease PPAR Research |
| title | PPARγ in Inflammatory Bowel Disease |
| title_full | PPARγ in Inflammatory Bowel Disease |
| title_fullStr | PPARγ in Inflammatory Bowel Disease |
| title_full_unstemmed | PPARγ in Inflammatory Bowel Disease |
| title_short | PPARγ in Inflammatory Bowel Disease |
| title_sort | pparγ in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2012/620839 |
| work_keys_str_mv | AT vitoannese ppargininflammatoryboweldisease AT francescarogai ppargininflammatoryboweldisease AT alessiasettesoldi ppargininflammatoryboweldisease AT sirobagnoli ppargininflammatoryboweldisease |