Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women
Objective To explore the differences of conventional ultrasound characteristics, elastic imaging parameters and clinicopathological characteristics of distinct molecular subtypes of breast cancer in young women, and to identify imaging parameters that exhibited significant associations with each mol...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2443041 |
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| author | Dian-xia Men Hui-zhan Li Juan Dong Meng-hua Xue Zhi-fen Wang Wen-li Xiao Ji-ping Xue Mei-hong Jia |
| author_facet | Dian-xia Men Hui-zhan Li Juan Dong Meng-hua Xue Zhi-fen Wang Wen-li Xiao Ji-ping Xue Mei-hong Jia |
| author_sort | Dian-xia Men |
| collection | DOAJ |
| description | Objective To explore the differences of conventional ultrasound characteristics, elastic imaging parameters and clinicopathological characteristics of distinct molecular subtypes of breast cancer in young women, and to identify imaging parameters that exhibited significant associations with each molecular subtype.Methods We performed a retrospective analysis encompassing 310 young women with breast cancer. Observations were made regarding the ultrasonography and elastography characteristics of the identified breast lesions. Subsequently, based on immunohistochemistry results patients were classified into five distinct molecular subtypes: luminal A, luminal B (HER2−), luminal B (HER2+), HER2+, and triple-negative breast cancer (TNBC). Clinical, pathological, and ultrasound imaging features were compared among these subtypes using binary logistic regression analysis.Results Statistically significant differences were observed in various parameters across the five molecular subtypes (p < 0.05), including tumor size, morphology, margins, calcification, posterior echo features, blood flow (Adler grading), and tumor hardness. Specifically, luminal A subtype exhibited propensity for spiculated margins, lower blood flow grading, and decreased hardness; luminal B subtype was characterized by angular margins; HER2+ subtype manifested higher blood flow grading, calcification, and elevated hardness. Conversely, TNBC subtype displayed smooth margins, absence of calcification, and heightened hardness.Conclusion Specific molecular subtypes of breast cancer have unique ultrasonic and elastic imaging characteristics. |
| format | Article |
| id | doaj-art-0d65ab2bb7a140cb94136aaa7f230ba2 |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-0d65ab2bb7a140cb94136aaa7f230ba22025-08-20T02:39:32ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2024.2443041Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young womenDian-xia Men0Hui-zhan Li1Juan Dong2Meng-hua Xue3Zhi-fen Wang4Wen-li Xiao5Ji-ping Xue6Mei-hong Jia7Department of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaDepartment of Ultrasonographl, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi Province, ChinaObjective To explore the differences of conventional ultrasound characteristics, elastic imaging parameters and clinicopathological characteristics of distinct molecular subtypes of breast cancer in young women, and to identify imaging parameters that exhibited significant associations with each molecular subtype.Methods We performed a retrospective analysis encompassing 310 young women with breast cancer. Observations were made regarding the ultrasonography and elastography characteristics of the identified breast lesions. Subsequently, based on immunohistochemistry results patients were classified into five distinct molecular subtypes: luminal A, luminal B (HER2−), luminal B (HER2+), HER2+, and triple-negative breast cancer (TNBC). Clinical, pathological, and ultrasound imaging features were compared among these subtypes using binary logistic regression analysis.Results Statistically significant differences were observed in various parameters across the five molecular subtypes (p < 0.05), including tumor size, morphology, margins, calcification, posterior echo features, blood flow (Adler grading), and tumor hardness. Specifically, luminal A subtype exhibited propensity for spiculated margins, lower blood flow grading, and decreased hardness; luminal B subtype was characterized by angular margins; HER2+ subtype manifested higher blood flow grading, calcification, and elevated hardness. Conversely, TNBC subtype displayed smooth margins, absence of calcification, and heightened hardness.Conclusion Specific molecular subtypes of breast cancer have unique ultrasonic and elastic imaging characteristics.https://www.tandfonline.com/doi/10.1080/07853890.2024.2443041Breast cancermolecular subtypeshear wave elastographyultrasonographyyoung women |
| spellingShingle | Dian-xia Men Hui-zhan Li Juan Dong Meng-hua Xue Zhi-fen Wang Wen-li Xiao Ji-ping Xue Mei-hong Jia Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women Annals of Medicine Breast cancer molecular subtype shear wave elastography ultrasonography young women |
| title | Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| title_full | Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| title_fullStr | Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| title_full_unstemmed | Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| title_short | Correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| title_sort | correlation between ultrasonography and elastography parameters and molecular subtypes of breast cancer in young women |
| topic | Breast cancer molecular subtype shear wave elastography ultrasonography young women |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2443041 |
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