ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65
ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at differe...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/196702 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850233114191724544 |
|---|---|
| author | Jing-kun Li Lei Cheng Yun-peng Zhao Ying-jun Guo Yi Liu Wei Zhang Shuai-shuai Wang Yuan-qiang Zhang Xin Pan Lin Nie |
| author_facet | Jing-kun Li Lei Cheng Yun-peng Zhao Ying-jun Guo Yi Liu Wei Zhang Shuai-shuai Wang Yuan-qiang Zhang Xin Pan Lin Nie |
| author_sort | Jing-kun Li |
| collection | DOAJ |
| description | ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upregulated in ONFH patients’ articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-α and Phospho-NF-κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH. |
| format | Article |
| id | doaj-art-0d63bbf92248489bb05988fa38047fe1 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0d63bbf92248489bb05988fa38047fe12025-08-20T02:03:00ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/196702196702ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65Jing-kun Li0Lei Cheng1Yun-peng Zhao2Ying-jun Guo3Yi Liu4Wei Zhang5Shuai-shuai Wang6Yuan-qiang Zhang7Xin Pan8Lin Nie9Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, ChinaDepartment of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, ChinaDepartment of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, ChinaMedical College of Shandong University, Jinan, Shandong 250012, ChinaMedical College of Shandong University, Jinan, Shandong 250012, ChinaMedical College of Shandong University, Jinan, Shandong 250012, ChinaMedical College of Shandong University, Jinan, Shandong 250012, ChinaMedical College of Shandong University, Jinan, Shandong 250012, ChinaDepartment of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, ChinaDepartment of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, ChinaADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upregulated in ONFH patients’ articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-α and Phospho-NF-κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.http://dx.doi.org/10.1155/2015/196702 |
| spellingShingle | Jing-kun Li Lei Cheng Yun-peng Zhao Ying-jun Guo Yi Liu Wei Zhang Shuai-shuai Wang Yuan-qiang Zhang Xin Pan Lin Nie ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 Mediators of Inflammation |
| title | ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 |
| title_full | ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 |
| title_fullStr | ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 |
| title_full_unstemmed | ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 |
| title_short | ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65 |
| title_sort | adamts 7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with tnf α and nf κb p65 |
| url | http://dx.doi.org/10.1155/2015/196702 |
| work_keys_str_mv | AT jingkunli adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT leicheng adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT yunpengzhao adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT yingjunguo adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT yiliu adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT weizhang adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT shuaishuaiwang adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT yuanqiangzhang adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT xinpan adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 AT linnie adamts7exhibitselevatedexpressionincartilageofosteonecrosisoffemoralheadandhasapositivecorrelationwithtnfaandnfkbp65 |