Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration

Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration

Abstract Background Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia and gut dysbiosis, may serve as a critical link between...

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Main Authors: Md. Samsuzzaman, Seong-Min Hong, Jae Hyuk Lee, Hyunjun Park, Keun-A Chang, Hyun-Bum Kim, Myoung Gyu Park, Hyeyoon Eo, Myung Sook Oh, Sun Yeou Kim
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biological Research
Subjects:
Depression
Tryptophan
Methylglyoxal
BDNF
Tau
MAPK
Online Access:https://doi.org/10.1186/s40659-024-00572-4
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