Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids
Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid with those isolated from other loci. Methodol...
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The Journal of Infection in Developing Countries
2017-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/8132 |
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| author | Xiumei Xiao Bei Yao Qingtao Zhou Jie Zhang |
| author_facet | Xiumei Xiao Bei Yao Qingtao Zhou Jie Zhang |
| author_sort | Xiumei Xiao |
| collection | DOAJ |
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Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid with those isolated from other loci.
Methodology: A total of 24 non-repetitive hvKP isolates were collected from January 2013 to June 2014 from patients with hvKP infections. There were 15 in Group 1 (fluid other than blood or abscess) and 9 in Group 2 (blood or abscess fluid). Medical records of all patients were reviewed. Capsular polysaccharide (CPS) typing, virulence factor determination, and multilocus sequence typing (MLST) of hvKP isolates were performed.
Results: Seventeen sequence types (STs) and 6 capsular serotypes were identified. Type K2CC65 was most commonly identified in Group 1 and type K2CC86 in Group 2. Deletion of pLVPK-derived loci were found in K2 and non-K1/K2 hvKP strains. Two virulent genes, fimH and ycfM, were identified more frequently in Group 2 than in Group 1. There was no difference in the frequency of other virulent genes or serotypes in the two groups. Two imipenem resistant hvKP isolates (cr-hvKP) were found in non-blood or abscess samples.
Conclusions: hvKP isolated from different body fluids had similar clinical and microbiological characteristics. cr-hvKP identified in non-blood or abscess samples should raise our attention to the challenging situation and management of hvKP infection.
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| format | Article |
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| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | The Journal of Infection in Developing Countries |
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| spelling | doaj-art-0d58c9a650e544faa94f987cb4d615dc2025-08-20T02:27:23ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802017-09-01110910.3855/jidc.8132Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluidsXiumei Xiao0Bei Yao1Qingtao Zhou2Jie Zhang3Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, ChinaPeking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, ChinaPeking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, ChinaPeking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid with those isolated from other loci. Methodology: A total of 24 non-repetitive hvKP isolates were collected from January 2013 to June 2014 from patients with hvKP infections. There were 15 in Group 1 (fluid other than blood or abscess) and 9 in Group 2 (blood or abscess fluid). Medical records of all patients were reviewed. Capsular polysaccharide (CPS) typing, virulence factor determination, and multilocus sequence typing (MLST) of hvKP isolates were performed. Results: Seventeen sequence types (STs) and 6 capsular serotypes were identified. Type K2CC65 was most commonly identified in Group 1 and type K2CC86 in Group 2. Deletion of pLVPK-derived loci were found in K2 and non-K1/K2 hvKP strains. Two virulent genes, fimH and ycfM, were identified more frequently in Group 2 than in Group 1. There was no difference in the frequency of other virulent genes or serotypes in the two groups. Two imipenem resistant hvKP isolates (cr-hvKP) were found in non-blood or abscess samples. Conclusions: hvKP isolated from different body fluids had similar clinical and microbiological characteristics. cr-hvKP identified in non-blood or abscess samples should raise our attention to the challenging situation and management of hvKP infection. https://jidc.org/index.php/journal/article/view/8132Hypermucoviscous Klebsiella pneumoniaehypermucoviscous Klebsiella pneumoniaemicrobiological characteristicsnon-blood/abscess samplevirulencefluid |
| spellingShingle | Xiumei Xiao Bei Yao Qingtao Zhou Jie Zhang Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids Journal of Infection in Developing Countries Hypermucoviscous Klebsiella pneumoniae hypermucoviscous Klebsiella pneumoniae microbiological characteristics non-blood/abscess sample virulence fluid |
| title | Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids |
| title_full | Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids |
| title_fullStr | Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids |
| title_full_unstemmed | Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids |
| title_short | Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids |
| title_sort | microbiological characteristics of hypermucoviscous klebsiella pneumoniae isolates from different body fluids |
| topic | Hypermucoviscous Klebsiella pneumoniae hypermucoviscous Klebsiella pneumoniae microbiological characteristics non-blood/abscess sample virulence fluid |
| url | https://jidc.org/index.php/journal/article/view/8132 |
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