Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies
The synthesis and antimicrobial activity of novel Zn(II) metal complexes derived from three novel heterocyclic Schiff base ligands 8-[(Z)-{[3-(N-methylamino)propyl]imino}methyl]-7-hydroxy-4-methyl-2H-chromen-2-one, 2-[(E)-{[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]imino}methyl]phenol, and (4S)-4-{4-[(...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2014/276598 |
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| author | Ramesh S. Yamgar Y. Nivid Satish Nalawade Mustapha Mandewale R. G. Atram Sudhir S. Sawant |
| author_facet | Ramesh S. Yamgar Y. Nivid Satish Nalawade Mustapha Mandewale R. G. Atram Sudhir S. Sawant |
| author_sort | Ramesh S. Yamgar |
| collection | DOAJ |
| description | The synthesis and antimicrobial activity of novel Zn(II) metal complexes derived from three novel heterocyclic Schiff base ligands 8-[(Z)-{[3-(N-methylamino)propyl]imino}methyl]-7-hydroxy-4-methyl-2H-chromen-2-one, 2-[(E)-{[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]imino}methyl]phenol, and (4S)-4-{4-[(E)-(2-hydroxybenzylidene)amino]benzyl}-1,3-oxazolidin-2-one have been described. These Schiff base ligands and metal complexes are characterised by spectroscopic techniques. According to these data, we propose an octahedral geometry to all the metal complexes. Antimicrobial activity of the Schiff base ligand and its metal complexes was studied against Gram negative bacteria: E. coli and Pseudomonas fluorescens, Gram positive bacteria: Staphylococcus aureus, and also against fungi, that is, C. albicans and A. niger. Some of the metal complexes show significant antifungal activity (MIC < 0.2 μg/mL). The “in vitro” data has identified [Zn(NMAPIMHMC)2]·2H2O, [Zn(TMPIMP)2]·2H2O, and [Zn(HBABO)2]·2H2O as potential therapeutic antifungal agents against C. albicans and A. niger. |
| format | Article |
| id | doaj-art-0d5373cc4d274f6ab8cb449b74a9aad8 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-0d5373cc4d274f6ab8cb449b74a9aad82025-02-03T07:24:31ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/276598276598Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial StudiesRamesh S. Yamgar0Y. Nivid1Satish Nalawade2Mustapha Mandewale3R. G. Atram4Sudhir S. Sawant5Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon (W), Mumbai 400 062, IndiaP. G. Department of Chemistry, Government of Maharashtra, Ismail Yusuf Arts, Science and Commerce College, Jogeshwari (East), Mumbai 400 060, IndiaP. G. Department of Chemistry, Government of Maharashtra, Ismail Yusuf Arts, Science and Commerce College, Jogeshwari (East), Mumbai 400 060, IndiaP. G. Department of Chemistry, Government of Maharashtra, Ismail Yusuf Arts, Science and Commerce College, Jogeshwari (East), Mumbai 400 060, IndiaP. G. Department of Chemistry, Government of Maharashtra, Ismail Yusuf Arts, Science and Commerce College, Jogeshwari (East), Mumbai 400 060, IndiaP. G. Department of Chemistry, Government of Maharashtra, Ismail Yusuf Arts, Science and Commerce College, Jogeshwari (East), Mumbai 400 060, IndiaThe synthesis and antimicrobial activity of novel Zn(II) metal complexes derived from three novel heterocyclic Schiff base ligands 8-[(Z)-{[3-(N-methylamino)propyl]imino}methyl]-7-hydroxy-4-methyl-2H-chromen-2-one, 2-[(E)-{[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]imino}methyl]phenol, and (4S)-4-{4-[(E)-(2-hydroxybenzylidene)amino]benzyl}-1,3-oxazolidin-2-one have been described. These Schiff base ligands and metal complexes are characterised by spectroscopic techniques. According to these data, we propose an octahedral geometry to all the metal complexes. Antimicrobial activity of the Schiff base ligand and its metal complexes was studied against Gram negative bacteria: E. coli and Pseudomonas fluorescens, Gram positive bacteria: Staphylococcus aureus, and also against fungi, that is, C. albicans and A. niger. Some of the metal complexes show significant antifungal activity (MIC < 0.2 μg/mL). The “in vitro” data has identified [Zn(NMAPIMHMC)2]·2H2O, [Zn(TMPIMP)2]·2H2O, and [Zn(HBABO)2]·2H2O as potential therapeutic antifungal agents against C. albicans and A. niger.http://dx.doi.org/10.1155/2014/276598 |
| spellingShingle | Ramesh S. Yamgar Y. Nivid Satish Nalawade Mustapha Mandewale R. G. Atram Sudhir S. Sawant Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies Bioinorganic Chemistry and Applications |
| title | Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies |
| title_full | Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies |
| title_fullStr | Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies |
| title_full_unstemmed | Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies |
| title_short | Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies |
| title_sort | novel zinc ii complexes of heterocyclic ligands as antimicrobial agents synthesis characterisation and antimicrobial studies |
| url | http://dx.doi.org/10.1155/2014/276598 |
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