Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks
Abstract Action tool knowledge can be assessed mainly with two kinds of tasks: tool-tool and hand-tool compatibility tasks. While these tasks are used to assess action tool knowledge, recent data showed striking dissociations between these tasks in brain-damaged patients. In this study, we explored...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07923-1 |
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| author | Mathieu Lesourd François Osiurak Julie Martin Sébastien Hague Margolise Laroze Gautier Clément Elisabeth Medeiros de Bustos Guillaume Fargeix Eloi Magnin Thierry Moulin |
| author_facet | Mathieu Lesourd François Osiurak Julie Martin Sébastien Hague Margolise Laroze Gautier Clément Elisabeth Medeiros de Bustos Guillaume Fargeix Eloi Magnin Thierry Moulin |
| author_sort | Mathieu Lesourd |
| collection | DOAJ |
| description | Abstract Action tool knowledge can be assessed mainly with two kinds of tasks: tool-tool and hand-tool compatibility tasks. While these tasks are used to assess action tool knowledge, recent data showed striking dissociations between these tasks in brain-damaged patients. In this study, we explored the neuropsychological dissociations (Experiment 1; 60 brain-damaged patients) and the potential cognitive mechanisms engaged during these two tasks (Experiment 2; 52 healthy participants). Finally, we also reanalyzed fMRI data to investigate the neural bases engaged in tool-tool and hand-tool compatibility tasks (Experiment 3; 34 healthy participants). The three experiments provide convergent arguments by showing that both tasks share common core computations supported by a left-lateralized brain network, but hand-tool compatibility task engages regions outside of this brain network and is explained by visual imagery while tool-tool task is rather explained by motor imagery. Our results shed a new light on action tool knowledge tasks. |
| format | Article |
| id | doaj-art-0d5366fdde1f4ad49ba4b73c4eb18b04 |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-0d5366fdde1f4ad49ba4b73c4eb18b042025-08-20T03:04:53ZengNature PortfolioCommunications Biology2399-36422025-04-018111410.1038/s42003-025-07923-1Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasksMathieu Lesourd0François Osiurak1Julie Martin2Sébastien Hague3Margolise Laroze4Gautier Clément5Elisabeth Medeiros de Bustos6Guillaume Fargeix7Eloi Magnin8Thierry Moulin9Université Marie et Louis Pasteur, INSERM, UMR 1322 LINCLaboratoire d’Étude des Mécanismes Cognitifs (EA 3082), Université Lyon 2Unité de Neurologie Vasculaire (UNV) et Hôpital de jour (HDJ), Service de Neurologie, CHRU de BesançonUnité de Neurologie Vasculaire (UNV) et Hôpital de jour (HDJ), Service de Neurologie, CHRU de BesançonUnité de Neurologie Vasculaire (UNV) et Hôpital de jour (HDJ), Service de Neurologie, CHRU de BesançonCentre Mémoire Ressources et Recherche (CMRR), service de Neurologie, CHRU BesançonUniversité Marie et Louis Pasteur, INSERM, UMR 1322 LINCUnité de Neurologie Vasculaire (UNV) et Hôpital de jour (HDJ), Service de Neurologie, CHRU de BesançonUniversité Marie et Louis Pasteur, INSERM, UMR 1322 LINCUniversité Marie et Louis Pasteur, INSERM, UMR 1322 LINCAbstract Action tool knowledge can be assessed mainly with two kinds of tasks: tool-tool and hand-tool compatibility tasks. While these tasks are used to assess action tool knowledge, recent data showed striking dissociations between these tasks in brain-damaged patients. In this study, we explored the neuropsychological dissociations (Experiment 1; 60 brain-damaged patients) and the potential cognitive mechanisms engaged during these two tasks (Experiment 2; 52 healthy participants). Finally, we also reanalyzed fMRI data to investigate the neural bases engaged in tool-tool and hand-tool compatibility tasks (Experiment 3; 34 healthy participants). The three experiments provide convergent arguments by showing that both tasks share common core computations supported by a left-lateralized brain network, but hand-tool compatibility task engages regions outside of this brain network and is explained by visual imagery while tool-tool task is rather explained by motor imagery. Our results shed a new light on action tool knowledge tasks.https://doi.org/10.1038/s42003-025-07923-1 |
| spellingShingle | Mathieu Lesourd François Osiurak Julie Martin Sébastien Hague Margolise Laroze Gautier Clément Elisabeth Medeiros de Bustos Guillaume Fargeix Eloi Magnin Thierry Moulin Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks Communications Biology |
| title | Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks |
| title_full | Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks |
| title_fullStr | Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks |
| title_full_unstemmed | Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks |
| title_short | Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks |
| title_sort | neurocognitive mechanisms underlying action tool knowledge tasks specificity of tool tool compared to hand tool compatibility tasks |
| url | https://doi.org/10.1038/s42003-025-07923-1 |
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