Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application
The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin. Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern. How...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2018/5475784 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849309150862901248 |
|---|---|
| author | Fabien Havas Shlomo Krispin Antonio J. Meléndez-Martínez Liki von Oppen-Bezalel |
| author_facet | Fabien Havas Shlomo Krispin Antonio J. Meléndez-Martínez Liki von Oppen-Bezalel |
| author_sort | Fabien Havas |
| collection | DOAJ |
| description | The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin. Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern. However, since the interest in these compounds in the context of many applications is expanding, it is important to conduct studies aimed at assessing their safety. We present here results of in vitro cytotoxicity and genotoxicity studies, revealing no significant cytotoxic or genotoxic potential and of short- and long-term human in vivo skin compatibility studies with phytoene- and phytofluene-rich tomato and Dunaliella salina alga extracts, showing a lack of irritancy or sensitization reactions. These results support the safe use of phytoene- and phytofluene-rich products in human topical applications. |
| format | Article |
| id | doaj-art-0d4a36f67e54417dbb3916fcf4fc5dda |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-0d4a36f67e54417dbb3916fcf4fc5dda2025-08-20T03:54:15ZengWileyJournal of Toxicology1687-81911687-82052018-01-01201810.1155/2018/54757845475784Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical ApplicationFabien Havas0Shlomo Krispin1Antonio J. Meléndez-Martínez2Liki von Oppen-Bezalel3IBR (Israeli Biotechnology Research) Ltd., 8122503 Yavne, IsraelIBR (Israeli Biotechnology Research) Ltd., 8122503 Yavne, IsraelDepartment of Nutrition & Food Science, Universidad de Sevilla, 41012 Seville, SpainIBR (Israeli Biotechnology Research) Ltd., 8122503 Yavne, IsraelThe colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin. Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern. However, since the interest in these compounds in the context of many applications is expanding, it is important to conduct studies aimed at assessing their safety. We present here results of in vitro cytotoxicity and genotoxicity studies, revealing no significant cytotoxic or genotoxic potential and of short- and long-term human in vivo skin compatibility studies with phytoene- and phytofluene-rich tomato and Dunaliella salina alga extracts, showing a lack of irritancy or sensitization reactions. These results support the safe use of phytoene- and phytofluene-rich products in human topical applications.http://dx.doi.org/10.1155/2018/5475784 |
| spellingShingle | Fabien Havas Shlomo Krispin Antonio J. Meléndez-Martínez Liki von Oppen-Bezalel Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application Journal of Toxicology |
| title | Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application |
| title_full | Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application |
| title_fullStr | Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application |
| title_full_unstemmed | Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application |
| title_short | Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application |
| title_sort | preliminary data on the safety of phytoene and phytofluene rich products for human use including topical application |
| url | http://dx.doi.org/10.1155/2018/5475784 |
| work_keys_str_mv | AT fabienhavas preliminarydataonthesafetyofphytoeneandphytofluenerichproductsforhumanuseincludingtopicalapplication AT shlomokrispin preliminarydataonthesafetyofphytoeneandphytofluenerichproductsforhumanuseincludingtopicalapplication AT antoniojmelendezmartinez preliminarydataonthesafetyofphytoeneandphytofluenerichproductsforhumanuseincludingtopicalapplication AT likivonoppenbezalel preliminarydataonthesafetyofphytoeneandphytofluenerichproductsforhumanuseincludingtopicalapplication |