Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following solid organ transplantation with an annual incidence rate of 3–5% in lung-transplant recipients. Pathogenesis indicates a strong association with functional over-immunosuppression and EBV infection. Clinical impro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/919651 |
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| author | Kamyar Afshar A. Purush Rao Vipul Patel Kevin Forrester Sivagini Ganesh |
| author_facet | Kamyar Afshar A. Purush Rao Vipul Patel Kevin Forrester Sivagini Ganesh |
| author_sort | Kamyar Afshar |
| collection | DOAJ |
| description | Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following solid organ transplantation with an annual incidence rate of 3–5% in lung-transplant recipients. Pathogenesis indicates a strong association with functional over-immunosuppression and EBV infection. Clinical improvement is generally observed with reduction in immunosuppression intensity alone. We present a case of a 24-year-old woman with EBV-associated PTLD following lung transplant where decreasing the immunosuppression improved PTLD but was ineffective against controlling the EBV infection. Foscarnet in combination with immunoglobulins was successfully administered to cause a remission of the EBV infection. This is the second case reported of a persistent EBV infection after reducing immunosuppression levels and evidence of PTLD remission that required foscarnet for EBV infection control. |
| format | Article |
| id | doaj-art-0d4942b1a38444fb91c69b9b63e9554c |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-0d4942b1a38444fb91c69b9b63e9554c2025-08-20T03:54:15ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/919651919651Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant RecipientKamyar Afshar0A. Purush Rao1Vipul Patel2Kevin Forrester3Sivagini Ganesh4Division of Pulmonary and Critical Care, University of Southern California, Keck School of Medicine, 2020 Zonal Avenue, IRD 723, Los Angeles, CA 90033, USADivision of Pulmonary and Critical Care, University of Southern California, Keck School of Medicine, 2020 Zonal Avenue, IRD 723, Los Angeles, CA 90033, USADivision of Pulmonary and Critical Care, University of Southern California, Keck School of Medicine, 2020 Zonal Avenue, IRD 723, Los Angeles, CA 90033, USADepartment of Clinical Pharmacy and Pharmaceutical Economics and Policy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USADivision of Pulmonary and Critical Care, University of Southern California, Keck School of Medicine, 2020 Zonal Avenue, IRD 723, Los Angeles, CA 90033, USAPosttransplant lymphoproliferative disorder (PTLD) is a serious complication following solid organ transplantation with an annual incidence rate of 3–5% in lung-transplant recipients. Pathogenesis indicates a strong association with functional over-immunosuppression and EBV infection. Clinical improvement is generally observed with reduction in immunosuppression intensity alone. We present a case of a 24-year-old woman with EBV-associated PTLD following lung transplant where decreasing the immunosuppression improved PTLD but was ineffective against controlling the EBV infection. Foscarnet in combination with immunoglobulins was successfully administered to cause a remission of the EBV infection. This is the second case reported of a persistent EBV infection after reducing immunosuppression levels and evidence of PTLD remission that required foscarnet for EBV infection control.http://dx.doi.org/10.1155/2011/919651 |
| spellingShingle | Kamyar Afshar A. Purush Rao Vipul Patel Kevin Forrester Sivagini Ganesh Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient Journal of Transplantation |
| title | Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient |
| title_full | Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient |
| title_fullStr | Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient |
| title_full_unstemmed | Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient |
| title_short | Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient |
| title_sort | use of foscarnet therapy for ebv infection following control of ptld with enhancement of cellular immunity in a lung transplant recipient |
| url | http://dx.doi.org/10.1155/2011/919651 |
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