Selective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma

Selective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma

Abstract Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer, and it demonstrates limited treatment options and worse survival. Identifications of a prognostic model and chemoresistance mechanism can be helpful for improving stratification and guiding therapy decisions. The...

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Main Authors: Liangdong Sun, Jue Wang, Huansha Yu, Xinsheng Zhu, Jing Zhang, Junjie Hu, Yilv Yan, Xun Zhang, Yuming Zhu, Gening Jiang, Ming Ding, Peng Zhang, Lele Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07595-x
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