Correlation of organelle interactions in the development of non-alcoholic fatty liver disease
Organelles, despite having distinct functions, interact with each other. Interactions between organelles typically occur at membrane contact sites (MCSs) to maintain cellular homeostasis, allowing the exchange of metabolites and other pieces of information required for normal cellular physiology. Im...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567743/full |
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| author | Jiabao Liao Jiabao Liao Mengqiu Shao Ze Zhou Si Wang You Lv Yanming Lu Fang Yao Wenting Li Ling Yang |
| author_facet | Jiabao Liao Jiabao Liao Mengqiu Shao Ze Zhou Si Wang You Lv Yanming Lu Fang Yao Wenting Li Ling Yang |
| author_sort | Jiabao Liao |
| collection | DOAJ |
| description | Organelles, despite having distinct functions, interact with each other. Interactions between organelles typically occur at membrane contact sites (MCSs) to maintain cellular homeostasis, allowing the exchange of metabolites and other pieces of information required for normal cellular physiology. Imbalances in organelle interactions may lead to various pathological processes. Increasing evidence suggests that abnormalorganelle interactions contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the key role of organelle interactions in NAFLD has not been fully evaluated and researched. In this review, we summarize the role of organelle interactions in NAFLD and emphasize their correlation with cellular calcium homeostasis, lipid transport, and mitochondrial dynamics. |
| format | Article |
| id | doaj-art-0d42e601005e4180abec2f24ae9678bd |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-0d42e601005e4180abec2f24ae9678bd2025-08-20T02:26:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15677431567743Correlation of organelle interactions in the development of non-alcoholic fatty liver diseaseJiabao Liao0Jiabao Liao1Mengqiu Shao2Ze Zhou3Si Wang4You Lv5Yanming Lu6Fang Yao7Wenting Li8Ling Yang9First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Endocrinology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaDepartment of Endocrinology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaFirst Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, ChinaOrganelles, despite having distinct functions, interact with each other. Interactions between organelles typically occur at membrane contact sites (MCSs) to maintain cellular homeostasis, allowing the exchange of metabolites and other pieces of information required for normal cellular physiology. Imbalances in organelle interactions may lead to various pathological processes. Increasing evidence suggests that abnormalorganelle interactions contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the key role of organelle interactions in NAFLD has not been fully evaluated and researched. In this review, we summarize the role of organelle interactions in NAFLD and emphasize their correlation with cellular calcium homeostasis, lipid transport, and mitochondrial dynamics.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567743/fullorganellesinteractionsMCSsNAFLDER |
| spellingShingle | Jiabao Liao Jiabao Liao Mengqiu Shao Ze Zhou Si Wang You Lv Yanming Lu Fang Yao Wenting Li Ling Yang Correlation of organelle interactions in the development of non-alcoholic fatty liver disease Frontiers in Immunology organelles interactions MCSs NAFLD ER |
| title | Correlation of organelle interactions in the development of non-alcoholic fatty liver disease |
| title_full | Correlation of organelle interactions in the development of non-alcoholic fatty liver disease |
| title_fullStr | Correlation of organelle interactions in the development of non-alcoholic fatty liver disease |
| title_full_unstemmed | Correlation of organelle interactions in the development of non-alcoholic fatty liver disease |
| title_short | Correlation of organelle interactions in the development of non-alcoholic fatty liver disease |
| title_sort | correlation of organelle interactions in the development of non alcoholic fatty liver disease |
| topic | organelles interactions MCSs NAFLD ER |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567743/full |
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