DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS
Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances w...
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Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute
2022-03-01
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| Series: | Фармация и фармакология (Пятигорск) |
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| Online Access: | https://www.pharmpharm.ru/jour/article/view/1026 |
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| author | A. O. Elagina A. V. Belyatskaya I. I. Krasnyuk (Jr.) I. I. Krasnyuk O. I. Stepanova T. V. Fateeva E. A. Smolyarchuk S. V. Kozin O. N. Plakhotnaya O. V. Rаstopchina J. V. Rau |
| author_facet | A. O. Elagina A. V. Belyatskaya I. I. Krasnyuk (Jr.) I. I. Krasnyuk O. I. Stepanova T. V. Fateeva E. A. Smolyarchuk S. V. Kozin O. N. Plakhotnaya O. V. Rаstopchina J. V. Rau |
| author_sort | A. O. Elagina |
| collection | DOAJ |
| description | Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press (“PRG”, VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations. |
| format | Article |
| id | doaj-art-0d40a569fc5144b7a5bac2bf7d14e5bd |
| institution | DOAJ |
| issn | 2307-9266 2413-2241 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute |
| record_format | Article |
| series | Фармация и фармакология (Пятигорск) |
| spelling | doaj-art-0d40a569fc5144b7a5bac2bf7d14e5bd2025-08-20T03:01:04ZrusVolgograd State Medical University, Pyatigorsk Medical and Pharmaceutical InstituteФармация и фармакология (Пятигорск)2307-92662413-22412022-03-01101556810.19163/2307-9266-2022-10-1-55-68423DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONSA. O. Elagina0A. V. Belyatskaya1I. I. Krasnyuk (Jr.)2I. I. Krasnyuk3O. I. Stepanova4T. V. Fateeva5E. A. Smolyarchuk6S. V. Kozin7O. N. Plakhotnaya8O. V. Rаstopchina9J. V. Rau10Sechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversityAll-Russian Research Institute of Medicinal and Aromatic PlantsSechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical University; Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR)Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press (“PRG”, VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations.https://www.pharmpharm.ru/jour/article/view/1026furazolidoneeffervescent tabletsinstant tabletssolid dispersionssolubilitydissolution ratepolyvinylpyrrolidone |
| spellingShingle | A. O. Elagina A. V. Belyatskaya I. I. Krasnyuk (Jr.) I. I. Krasnyuk O. I. Stepanova T. V. Fateeva E. A. Smolyarchuk S. V. Kozin O. N. Plakhotnaya O. V. Rаstopchina J. V. Rau DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS Фармация и фармакология (Пятигорск) furazolidone effervescent tablets instant tablets solid dispersions solubility dissolution rate polyvinylpyrrolidone |
| title | DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS |
| title_full | DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS |
| title_fullStr | DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS |
| title_full_unstemmed | DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS |
| title_short | DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS |
| title_sort | development of nitrofuran derivative composition and technology of effervescent tablets with solid dispersions |
| topic | furazolidone effervescent tablets instant tablets solid dispersions solubility dissolution rate polyvinylpyrrolidone |
| url | https://www.pharmpharm.ru/jour/article/view/1026 |
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