Periodontitis Home Screening with Mouth Rinse Cut-Off 20 Ng/mL aMMP-8 Test and Mobile Application
<b>Background:</b> In this study, we describe a method by which a patient can independently assess their own periodontitis risk, for example, at home, with a mobile application. The aim of the study is to use active matrix metalloproteinase aMMP-8 mouth rinse cut-off 20 ng/mL point-of-ca...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/3/296 |
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| Summary: | <b>Background:</b> In this study, we describe a method by which a patient can independently assess their own periodontitis risk, for example, at home, with a mobile application. The aim of the study is to use active matrix metalloproteinase aMMP-8 mouth rinse cut-off 20 ng/mL point-of-care testing (POCT) and a polynomial function to reveal patients’ statistical risk of periodontitis. <b>Methods:</b> The polynomial function presented in this study was modeled with multiple logistic regression and the function estimates the risk of periodontitis using a probability measure. To investigate variables associated with periodontitis, we used data from adult patients visiting dental clinics in Thessaloniki, Greece. <b>Results:</b> The research results revealed that with appropriate information it is possible to obtain sufficient accuracy about a patient’s potential risk of periodontitis. The function for estimating risk of periodontitis is PERIORISK = (1 + e<sup>−(3.392×X1+0.002×X2+1.858×X3−9.151)</sup>)<sup>−1</sup>, where X1 = aMMP-8 test result and tobacco smoking status, X2 = age × waist circumference and X3 = patient’s individual and parental history of diabetes. <b>Conclusions:</b> The prediction of periodontitis risk using an aMMP-8 test and a polynomial function seems to be a useful, non-invasive, safe-to-use and cost-effective tool for all people. Overall, in the model created, mouth rinse cut-off 20 ng/mL aMMP-8 test result, age, waist circumference, tobacco smoking status and patient’s individual and parental history of diabetes were found to be good factors explaining the risk of periodontitis. |
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| ISSN: | 2075-4418 |