Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases

Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases

Abstract Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK networks both experimentally and in silico has been hind...

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Bibliographic Details
Main Authors: András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi
Format: Article
Language:English
Published: Springer Nature 2015-11-01
Series:Molecular Systems Biology
Subjects:
cellular signaling
linear motif
MAP kinase
protein–protein interaction
Online Access:https://doi.org/10.15252/msb.20156269
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