Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols
Airway irritation effects after single and repeated inhalation exposures to aerosols of β-glucan (grifolan) were investigated in mice. In addition, the effects on serum total immunoglobulin E (IgE) production and histopathological inflammation in the respiratory tract were studied. The β-glucan aero...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/0962935031000134851 |
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| author | A. Korpi J.-p. Kasanen V.-m. Kosma R. Rylander A.-l. Pasanen |
| author_facet | A. Korpi J.-p. Kasanen V.-m. Kosma R. Rylander A.-l. Pasanen |
| author_sort | A. Korpi |
| collection | DOAJ |
| description | Airway irritation effects after single and repeated inhalation exposures to aerosols of β-glucan (grifolan) were investigated in mice. In addition, the effects on serum total immunoglobulin E (IgE) production and histopathological inflammation in the respiratory tract were studied. The β-glucan aerosols provoked slight sensory irritation in the airways, but the response was not concentration dependent at the levels studied. Slight pulmonary irritation was observed after repeated exposures. No effect was found on the serum total IgE levels, and no signs of inflammation were seen in the airways 6 h after the final exposure. The results suggest that, irrespective of previous fungal sensitization of the animals, inhaled β-glucan may cause symptoms of respiratory tract irritation but without apparent inflammation. Respiratory tract irritation reported after inhalation of fungi may not be entirely attributed to β-glucan. |
| format | Article |
| id | doaj-art-0d2f4ad487704846bc530513c5f00be4 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0d2f4ad487704846bc530513c5f00be42025-08-20T02:03:04ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112313914610.1080/0962935031000134851Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosolsA. Korpi0J.-p. Kasanen1V.-m. Kosma2R. Rylander3A.-l. Pasanen4Department of Environmental Sciences, University of Kuopio, P.O. Box 1627, Kuopio 70211, FinlandDepartment of Environmental Sciences, University of Kuopio, P.O. Box 1627, Kuopio 70211, FinlandDepartment of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, FinlandDepartment of Environmental Medicine, University of Gothenburg, Gothenburg, SwedenDepartment of Environmental Sciences, University of Kuopio, P.O. Box 1627, Kuopio 70211, FinlandAirway irritation effects after single and repeated inhalation exposures to aerosols of β-glucan (grifolan) were investigated in mice. In addition, the effects on serum total immunoglobulin E (IgE) production and histopathological inflammation in the respiratory tract were studied. The β-glucan aerosols provoked slight sensory irritation in the airways, but the response was not concentration dependent at the levels studied. Slight pulmonary irritation was observed after repeated exposures. No effect was found on the serum total IgE levels, and no signs of inflammation were seen in the airways 6 h after the final exposure. The results suggest that, irrespective of previous fungal sensitization of the animals, inhaled β-glucan may cause symptoms of respiratory tract irritation but without apparent inflammation. Respiratory tract irritation reported after inhalation of fungi may not be entirely attributed to β-glucan.http://dx.doi.org/10.1080/0962935031000134851Fungal cell-wall componentGrifolanInhalation exposureMice. |
| spellingShingle | A. Korpi J.-p. Kasanen V.-m. Kosma R. Rylander A.-l. Pasanen Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols Mediators of Inflammation Fungal cell-wall component Grifolan Inhalation exposure Mice. |
| title | Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols |
| title_full | Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols |
| title_fullStr | Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols |
| title_full_unstemmed | Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols |
| title_short | Slight respiratory irritation but not inflammation in mice exposed to (1→3)-β-D-glucan aerosols |
| title_sort | slight respiratory irritation but not inflammation in mice exposed to 1 3 β d glucan aerosols |
| topic | Fungal cell-wall component Grifolan Inhalation exposure Mice. |
| url | http://dx.doi.org/10.1080/0962935031000134851 |
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