PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA
Abstract. Present study dealt with efficiency of melatonin implementation in a combination therapeutic schedule of bronchial asthma (BA). A group of 248 patients with atopic, or mixed clinical forms of BA being in exacerbation, or medication remission state, and 36 healthy donors were included into...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/613 |
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| author | G. I. Litvinenko A. V. Shurlygina V. S. Shirinsky V. M. Nepomnjаshih I. V. Shirinsky V. A. Trufakin |
| author_facet | G. I. Litvinenko A. V. Shurlygina V. S. Shirinsky V. M. Nepomnjаshih I. V. Shirinsky V. A. Trufakin |
| author_sort | G. I. Litvinenko |
| collection | DOAJ |
| description | Abstract. Present study dealt with efficiency of melatonin implementation in a combination therapeutic schedule of bronchial asthma (BA). A group of 248 patients with atopic, or mixed clinical forms of BA being in exacerbation, or medication remission state, and 36 healthy donors were included into the study. Melatonin (Melaxen, Unifarm, USA) was administered as a single daily dose of 0.003 g, at 21.00, accompanied by a standard therapy in twenty BA patients for 21 days. We determined contents and functional properties of Т- and B-lymphocytes, mononuclear phagocytes, IgE, IL-4, IFNγ levels, as well as melatonin concentrations in blood serum in the morning and evening time. When included into BA treatment protocol, melatonin proved to cause partial restoration of circadian rhythm for Tand B cell subpopulations, mononuclear phagocytes, cytokine production, due to its chronotropic and immunomodulating activity. This effect is associated with a more pronounced clinical effect, thus presuming reversibility of desynchronosis state. |
| format | Article |
| id | doaj-art-0d2a5554b86e4c9e97ffd35dd4c63c09 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-0d2a5554b86e4c9e97ffd35dd4c63c092025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114653354010.15789/1563-0625-2012-6-533-540610PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMAG. I. Litvinenko0A. V. Shurlygina1V. S. Shirinsky2V. M. Nepomnjаshih3I. V. Shirinsky4V. A. Trufakin5ФГБУ «Научно-исследовательский институт клинической и экспериментальной лимфологии» СО РАМН, г. НовосибирскФГБУ «Научно-исследовательский институт клинической и экспериментальной лимфологии» СО РАМН, г. НовосибирскФГБУ «Научно-исследовательский институт клинической иммунологии» СО РАМН, г. НовосибирскФГБУ «Научно-исследовательский институт клинической иммунологии» СО РАМН, г. НовосибирскФГБУ «Научно-исследовательский институт клинической иммунологии» СО РАМН, г. НовосибирскФГБУ «Научно-исследовательский институт физиологии» СО РАМН, г. НовосибирскAbstract. Present study dealt with efficiency of melatonin implementation in a combination therapeutic schedule of bronchial asthma (BA). A group of 248 patients with atopic, or mixed clinical forms of BA being in exacerbation, or medication remission state, and 36 healthy donors were included into the study. Melatonin (Melaxen, Unifarm, USA) was administered as a single daily dose of 0.003 g, at 21.00, accompanied by a standard therapy in twenty BA patients for 21 days. We determined contents and functional properties of Т- and B-lymphocytes, mononuclear phagocytes, IgE, IL-4, IFNγ levels, as well as melatonin concentrations in blood serum in the morning and evening time. When included into BA treatment protocol, melatonin proved to cause partial restoration of circadian rhythm for Tand B cell subpopulations, mononuclear phagocytes, cytokine production, due to its chronotropic and immunomodulating activity. This effect is associated with a more pronounced clinical effect, thus presuming reversibility of desynchronosis state.https://www.mimmun.ru/mimmun/article/view/613melatoninimmune statusbronchial asthma |
| spellingShingle | G. I. Litvinenko A. V. Shurlygina V. S. Shirinsky V. M. Nepomnjаshih I. V. Shirinsky V. A. Trufakin PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA Медицинская иммунология melatonin immune status bronchial asthma |
| title | PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_full | PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_fullStr | PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_full_unstemmed | PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_short | PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_sort | pathogenetic justification and efficiency of melatonin application in patients with bronchial asthma |
| topic | melatonin immune status bronchial asthma |
| url | https://www.mimmun.ru/mimmun/article/view/613 |
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