Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria

Abstract The npmA gene, encoding a 16S rRNA methyltransferase, confers resistance to all clinically available aminoglycosides, posing a significant threat to effective antibiotic therapy. We analyze 1,932,812 bacterial genomes to investigate the distribution and mobilization of npmA variants. npmA i...

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Bibliographic Details
Main Authors: Carlos Serna, Bosco R. Matamoros, Mario Pulido-Vadillo, Jose F. Delgado-Blas, Rogier R. Jansen, Rob J. L. Willems, Alexandre Almeida, Ewan M. Harrison, Bruno Dupuy, Francesc Coll, Bruno Gonzalez-Zorn
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61152-y
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