The emerging role of Nrf2 in dermatotoxicology

Abstract The nuclear factor erythroid 2‐related factor 2 (Nrf2) is best known for its role in resistance to oxidant stress. In this issue of EMBO Molecular Medicine, Nrf2‐prolonged genetic activation is shown with devastating effects on skin homeostasis. The study provides novel molecular insights i...

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Bibliographic Details
Main Authors: Nguan S Tan, Walter Wahli
Format: Article
Language:English
Published: Springer Nature 2014-02-01
Series:EMBO Molecular Medicine
Online Access:https://doi.org/10.1002/emmm.201303797
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Summary:Abstract The nuclear factor erythroid 2‐related factor 2 (Nrf2) is best known for its role in resistance to oxidant stress. In this issue of EMBO Molecular Medicine, Nrf2‐prolonged genetic activation is shown with devastating effects on skin homeostasis. The study provides novel molecular insights into poison‐induced chloracne and metabolizing acquired dioxin‐induced skin hamartomas or MADISH.
ISSN:1757-4676
1757-4684