Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

Streptococcus pyogenes causes mild human infections as well as life-threatening invasive diseases. Since the mutations known to enhance virulence to date account for only half of the severe invasive infections, additional mechanisms/mutations need to be identified. Here, we conducted a genome-wide a...

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Main Authors: Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Tomoko Sumitomo, Tohru Miyoshi-Akiyama, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara, Hitoshi Otsuka, Noriko Nakanishi, Yu Kazawa, Chikara Nakagawa, Ryo Yamaguchi, Hiroo Sakai, Yuko Matsumoto, Tadayoshi Ikebe, Shigetada Kawabata
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
pangenome-wide association study
pangenome analysis
invasive infections
ferric iron transporter
Streptococcus pyogenes
Online Access:https://elifesciences.org/articles/101938
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