The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia
21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) is associated with cardiovascular risk factors such as, hypertension, obesity, dyslipidemia, and insulin resistance. It is not known whether 21-hydroxylase-deficient CAH is risk factor for atrial and ventricular arrhythmias. The purpose...
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Hacettepe University Institute of Child Health
2019-04-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/678 |
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| author | Hüseyin Anıl Korkmaz Rahmi Özdemir Mehmet Küçük Cem Karadeniz Timur Meşe Behzat Özkan |
| author_facet | Hüseyin Anıl Korkmaz Rahmi Özdemir Mehmet Küçük Cem Karadeniz Timur Meşe Behzat Özkan |
| author_sort | Hüseyin Anıl Korkmaz |
| collection | DOAJ |
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21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) is associated with cardiovascular risk factors such as, hypertension, obesity, dyslipidemia, and insulin resistance. It is not known whether 21-hydroxylase-deficient CAH is risk factor for atrial and ventricular arrhythmias. The purpose of this study was to compare the 12-lead electrocardiographic measures in patients of 21-hydroxylase-deficient congenital adrenal hyperplasia with those in healthy control subjects matched for age, sex, height, weight and body mass index (BMI). Twenty-five patients with 21-hydroxylase-deficient CAH and twenty-five heathy control subjects were enrolled into this observational, cross-sectional, controlled study. The evaluation consisted of anthropometric measurements, biochemical parameters, and electrocardiographic (ECG) measures. The standard 12-lead electrocardiography was performed in all patients and P-wave dispersion (PWd), QT interval, QTd, QTcd, Tp-e dispersion, Tp-e/QT and Tp-e/QTc ratios were calculated. There were no significant differences in the groups for age, sex, height, weight and BMI (median age 9.4 (1.5-16.75) years, mean weight 37.6±21.5 vs. 27.9±18.3 kg, mean height 125.4±28.9 vs. 114.7±31 cm, mean BMI 21.4±5.7 vs. 18.9±3.4 kg/m2, respectively). P dispersion and Tp-e dispersion were significantly higher in patients of 21-hydroxylase-deficient CAH compared to the healthy subjects (median P dispersion 50 (25) vs. 40 (40) ms, mean Tp-e dispersion 48±15.5 vs. 35.2±17.5 ms). Our study revealed that 21-hydroxylase deficient CAH is associated with high risk of atrial and ventricular arrhythmias in children.
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| format | Article |
| id | doaj-art-0d1eefc5d3034bf0b44ef2f81d679337 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-0d1eefc5d3034bf0b44ef2f81d6793372025-08-20T03:00:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212019-04-0161210.24953/turkjped.2019.02.011The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasiaHüseyin Anıl Korkmaz0Rahmi Özdemir1Mehmet Küçük2Cem Karadeniz3Timur Meşe4Behzat Özkan5Divisions of Pediatric Endocrinology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Endocrinology, Department of Pediatrics, İzmir Dr. Behcet Uz Children's Hospital, İzmir, Turkey. 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) is associated with cardiovascular risk factors such as, hypertension, obesity, dyslipidemia, and insulin resistance. It is not known whether 21-hydroxylase-deficient CAH is risk factor for atrial and ventricular arrhythmias. The purpose of this study was to compare the 12-lead electrocardiographic measures in patients of 21-hydroxylase-deficient congenital adrenal hyperplasia with those in healthy control subjects matched for age, sex, height, weight and body mass index (BMI). Twenty-five patients with 21-hydroxylase-deficient CAH and twenty-five heathy control subjects were enrolled into this observational, cross-sectional, controlled study. The evaluation consisted of anthropometric measurements, biochemical parameters, and electrocardiographic (ECG) measures. The standard 12-lead electrocardiography was performed in all patients and P-wave dispersion (PWd), QT interval, QTd, QTcd, Tp-e dispersion, Tp-e/QT and Tp-e/QTc ratios were calculated. There were no significant differences in the groups for age, sex, height, weight and BMI (median age 9.4 (1.5-16.75) years, mean weight 37.6±21.5 vs. 27.9±18.3 kg, mean height 125.4±28.9 vs. 114.7±31 cm, mean BMI 21.4±5.7 vs. 18.9±3.4 kg/m2, respectively). P dispersion and Tp-e dispersion were significantly higher in patients of 21-hydroxylase-deficient CAH compared to the healthy subjects (median P dispersion 50 (25) vs. 40 (40) ms, mean Tp-e dispersion 48±15.5 vs. 35.2±17.5 ms). Our study revealed that 21-hydroxylase deficient CAH is associated with high risk of atrial and ventricular arrhythmias in children. https://turkjpediatr.org/article/view/67821– hydroxylase deficiencychildrenelectrocardiographic measuresventricular arrhythmias |
| spellingShingle | Hüseyin Anıl Korkmaz Rahmi Özdemir Mehmet Küçük Cem Karadeniz Timur Meşe Behzat Özkan The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia The Turkish Journal of Pediatrics 21– hydroxylase deficiency children electrocardiographic measures ventricular arrhythmias |
| title | The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia |
| title_full | The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia |
| title_fullStr | The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia |
| title_full_unstemmed | The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia |
| title_short | The impact of 21-hydroxylase deficiency on cardiac repolarization changes in children with 21-hydroxylasedeficient congenital adrenal hyperplasia |
| title_sort | impact of 21 hydroxylase deficiency on cardiac repolarization changes in children with 21 hydroxylasedeficient congenital adrenal hyperplasia |
| topic | 21– hydroxylase deficiency children electrocardiographic measures ventricular arrhythmias |
| url | https://turkjpediatr.org/article/view/678 |
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