Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient
A 40-year-old male who was found to be human immunodeficiency virus-positive when he presented with bloody diarrhea in 1986 is described. Clinical, laboratory, endoscopic and histological findings were all compatible with ulcerative colitis, and stool cultures were repeatedly negative for pathogens....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/676591 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564450214805504 |
|---|---|
| author | David C Pearson Lloyd R Sutherland Stephan Urbanski |
| author_facet | David C Pearson Lloyd R Sutherland Stephan Urbanski |
| author_sort | David C Pearson |
| collection | DOAJ |
| description | A 40-year-old male who was found to be human immunodeficiency virus-positive when he presented with bloody diarrhea in 1986 is described. Clinical, laboratory, endoscopic and histological findings were all compatible with ulcerative colitis, and stool cultures were repeatedly negative for pathogens. Colitis was initially mild and controlled with intermittent oral aminosalicylic acid products. Since 1993 he has had more significant symptoms requiring prednisone up to 40 mg/day. Repeat colonoscopy disclosed pancolitis and biopsies did not show evidence of cytomegalovirus infection. He has not had an acquired immune deficiency syndrome-defining illness. CD4 cells fell below normal as his colitis worsened. This case raises questions about immune regulation in ulcerative colitis because the patient has active disease in addition to a reduced number of T helper cells. It also presents a difficult management problem because the patient has a limited life expectancy and is reluctant to accept colectomy, and further immunosuppressive therapy may be dangerous. |
| format | Article |
| id | doaj-art-0d1dc733a19e4d1cb8cf2555f07be863 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-0d1dc733a19e4d1cb8cf2555f07be8632025-02-03T01:10:51ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-0110530730910.1155/1996/676591Pas de Deux: Active Ulcerative Colitis in an HIV-Positive PatientDavid C Pearson0Lloyd R Sutherland1Stephan Urbanski2Departments of Medicine and Pathology, University of Calgary, Calgary, Alberta, CanadaDepartments of Medicine and Pathology, University of Calgary, Calgary, Alberta, CanadaDepartments of Medicine and Pathology, University of Calgary, Calgary, Alberta, CanadaA 40-year-old male who was found to be human immunodeficiency virus-positive when he presented with bloody diarrhea in 1986 is described. Clinical, laboratory, endoscopic and histological findings were all compatible with ulcerative colitis, and stool cultures were repeatedly negative for pathogens. Colitis was initially mild and controlled with intermittent oral aminosalicylic acid products. Since 1993 he has had more significant symptoms requiring prednisone up to 40 mg/day. Repeat colonoscopy disclosed pancolitis and biopsies did not show evidence of cytomegalovirus infection. He has not had an acquired immune deficiency syndrome-defining illness. CD4 cells fell below normal as his colitis worsened. This case raises questions about immune regulation in ulcerative colitis because the patient has active disease in addition to a reduced number of T helper cells. It also presents a difficult management problem because the patient has a limited life expectancy and is reluctant to accept colectomy, and further immunosuppressive therapy may be dangerous.http://dx.doi.org/10.1155/1996/676591 |
| spellingShingle | David C Pearson Lloyd R Sutherland Stephan Urbanski Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient Canadian Journal of Gastroenterology |
| title | Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient |
| title_full | Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient |
| title_fullStr | Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient |
| title_full_unstemmed | Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient |
| title_short | Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient |
| title_sort | pas de deux active ulcerative colitis in an hiv positive patient |
| url | http://dx.doi.org/10.1155/1996/676591 |
| work_keys_str_mv | AT davidcpearson pasdedeuxactiveulcerativecolitisinanhivpositivepatient AT lloydrsutherland pasdedeuxactiveulcerativecolitisinanhivpositivepatient AT stephanurbanski pasdedeuxactiveulcerativecolitisinanhivpositivepatient |