The Influence of Interleukin 6 Knockout on Age-Related Degenerative Changes in the Cerebellar Cortex of Mice

The Influence of Interleukin 6 Knockout on Age-Related Degenerative Changes in the Cerebellar Cortex of Mice

This study investigates age-related neurodegeneration in the cerebellar cortex, emphasizing the role of IL-6 deficiency in preserving Purkinje cells. We found that apoptosis plays a minimal role in Purkinje cell loss by using 4-month- and 24-month-old wild-type (WT) and IL-6 knockout (IL-6KO) mice....

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Bibliographic Details
Main Authors: Magdalena Wiktoria Cieślińska, Izabela Bialuk, Magdalena Dziemidowicz, Beata Szynaka, Joanna Reszeć-Giełażyn, Maria Małgorzata Winnicka, Tomasz Andrzej Bonda
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
IL-6 deficiency
Purkinje cells
aging
p53
Online Access:https://www.mdpi.com/2073-4409/14/7/532
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