The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease
Placental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beg...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/638476 |
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| author | Stephanie E. Hallows Timothy R. H. Regnault Dean H. Betts |
| author_facet | Stephanie E. Hallows Timothy R. H. Regnault Dean H. Betts |
| author_sort | Stephanie E. Hallows |
| collection | DOAJ |
| description | Placental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beginning to be elucidated, and premature aging or cellular senescence through increased oxidative stress and DNA damage to telomeric ends may be initiators of these disease processes. This paper will explore the areas where telomere and telomerase biology can have significant effects on various tissues in the body in IUGR outcomes. |
| format | Article |
| id | doaj-art-0d1aa27906944952bfbc24ce15fe0eb8 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-0d1aa27906944952bfbc24ce15fe0eb82025-02-03T05:53:31ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/638476638476The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult DiseaseStephanie E. Hallows0Timothy R. H. Regnault1Dean H. Betts2Department of Physiology and Pharmacology, University of Western Ontario, Ontario, London, ON, N6A 5C1, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, Ontario, London, ON, N6A 5C1, CanadaDepartment of Physiology and Pharmacology, University of Western Ontario, Ontario, London, ON, N6A 5C1, CanadaPlacental insufficiency, maternal malnutrition, and other causes of intrauterine growth restriction (IUGR) can significantly affect short-term growth and long-term health. Following IUGR, there is an increased risk for cardiovascular disease and Type 2 Diabetes. The etiology of these diseases is beginning to be elucidated, and premature aging or cellular senescence through increased oxidative stress and DNA damage to telomeric ends may be initiators of these disease processes. This paper will explore the areas where telomere and telomerase biology can have significant effects on various tissues in the body in IUGR outcomes.http://dx.doi.org/10.1155/2012/638476 |
| spellingShingle | Stephanie E. Hallows Timothy R. H. Regnault Dean H. Betts The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease Journal of Pregnancy |
| title | The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease |
| title_full | The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease |
| title_fullStr | The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease |
| title_full_unstemmed | The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease |
| title_short | The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease |
| title_sort | long and short of it the role of telomeres in fetal origins of adult disease |
| url | http://dx.doi.org/10.1155/2012/638476 |
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