Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure
Abstract Treadmill exercise tests assess aerobic capacity in chronic heart failure (CHF) mice, but subjective exhaustion criteria limit reproducibility. Elevated blood lactate (La) at exhaustion may provide an objective fatigue marker. This study evaluated La at exhaustion and the effects of exercis...
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Wiley
2025-08-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70485 |
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| author | Ahmed M. Wafi Lie Gao Irving H. Zucker |
| author_facet | Ahmed M. Wafi Lie Gao Irving H. Zucker |
| author_sort | Ahmed M. Wafi |
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| description | Abstract Treadmill exercise tests assess aerobic capacity in chronic heart failure (CHF) mice, but subjective exhaustion criteria limit reproducibility. Elevated blood lactate (La) at exhaustion may provide an objective fatigue marker. This study evaluated La at exhaustion and the effects of exercise training (ExT) on resting La in CHF mice. Sham and coronary artery ligation‐induced CHF mice were assigned to sedentary (Sed) or ExT groups. Blood La was measured from 0.7 μL tail vein samples at rest and at exhaustion during exercise tests after 8 weeks of ExT. Blood La at rest was slightly higher in CHF‐Sed mice (3.33 ± 1.23 mmol/L) than in Sham‐Sed mice (2.96 ± 0.42 mmol/L; p = 0.86). ExT slightly reduced La in CHF mice (2.55 ± 0.63 mmol/L; p = 0.34 vs. CHF‐Sed), but differences were not significant. At exhaustion, blood La increased significantly across groups. Baseline La in CHF‐Sed mice negatively correlated with running distance (r = −0.84, p = 0.03). Blood La levels at exhaustion offer a cost‐effective method to confirm exhaustion criteria and enhance the reliability of exercise tests. La at rest may not reflect CHF severity or exercise adaptation but correlates better with exercise capacity in CHF. |
| format | Article |
| id | doaj-art-0d16dbedb49b41c982aa9793d9f8cbc4 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
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| spelling | doaj-art-0d16dbedb49b41c982aa9793d9f8cbc42025-08-20T03:44:14ZengWileyPhysiological Reports2051-817X2025-08-011315n/an/a10.14814/phy2.70485Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failureAhmed M. Wafi0Lie Gao1Irving H. Zucker2Basic Medical Science Department, Faculty of Medicine Jazan University Jazan Saudi ArabiaDepartment of Anesthesiology University of Nebraska Medical Center Omaha Nebraska USADepartment of Cellular and Integrative Physiology University of Nebraska Medical Center Omaha Nebraska USAAbstract Treadmill exercise tests assess aerobic capacity in chronic heart failure (CHF) mice, but subjective exhaustion criteria limit reproducibility. Elevated blood lactate (La) at exhaustion may provide an objective fatigue marker. This study evaluated La at exhaustion and the effects of exercise training (ExT) on resting La in CHF mice. Sham and coronary artery ligation‐induced CHF mice were assigned to sedentary (Sed) or ExT groups. Blood La was measured from 0.7 μL tail vein samples at rest and at exhaustion during exercise tests after 8 weeks of ExT. Blood La at rest was slightly higher in CHF‐Sed mice (3.33 ± 1.23 mmol/L) than in Sham‐Sed mice (2.96 ± 0.42 mmol/L; p = 0.86). ExT slightly reduced La in CHF mice (2.55 ± 0.63 mmol/L; p = 0.34 vs. CHF‐Sed), but differences were not significant. At exhaustion, blood La increased significantly across groups. Baseline La in CHF‐Sed mice negatively correlated with running distance (r = −0.84, p = 0.03). Blood La levels at exhaustion offer a cost‐effective method to confirm exhaustion criteria and enhance the reliability of exercise tests. La at rest may not reflect CHF severity or exercise adaptation but correlates better with exercise capacity in CHF.https://doi.org/10.14814/phy2.70485blood lactatechronic heart failureexercise trainingfatigueincremental exercise test |
| spellingShingle | Ahmed M. Wafi Lie Gao Irving H. Zucker Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure Physiological Reports blood lactate chronic heart failure exercise training fatigue incremental exercise test |
| title | Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| title_full | Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| title_fullStr | Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| title_full_unstemmed | Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| title_short | Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| title_sort | blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure |
| topic | blood lactate chronic heart failure exercise training fatigue incremental exercise test |
| url | https://doi.org/10.14814/phy2.70485 |
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