Interrelation of auto-immune process, endocrine disorders and depression
Disturbances in immune and endocrine regulation are closely interrelated with development of psychiatric diseases, including affective disorders. Depression may be a characteristic of at least 23 autoimmune diseases. Negative influence on the depression development have: an increased level of proinf...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2020-04-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/379 |
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| _version_ | 1849388977981751296 |
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| author | M. A. Mayorova N. N. Petrova U. I. Stroev L. P. Churilov Y. Shoenfeld |
| author_facet | M. A. Mayorova N. N. Petrova U. I. Stroev L. P. Churilov Y. Shoenfeld |
| author_sort | M. A. Mayorova |
| collection | DOAJ |
| description | Disturbances in immune and endocrine regulation are closely interrelated with development of psychiatric diseases, including affective disorders. Depression may be a characteristic of at least 23 autoimmune diseases. Negative influence on the depression development have: an increased level of proinflammatory cytokines, impairment of T-regulatory cells, kynurenine pathway shift towards production of its potentially neurotoxic metabolites, overproduction of stress hormones, hyperleptinemia, hyperprolactinemia, hypothyroidism, as well as vitamin D, calcidiol and calcitriol deficiency. In this review we analysed the development and accumulation of ideas and facts regarding the interrelation between autoimmune and affective pathology. |
| format | Article |
| id | doaj-art-0d0f130264e64355b96743ebf292a55a |
| institution | Kabale University |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-0d0f130264e64355b96743ebf292a55a2025-08-20T03:42:06ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2020-04-010181910.31363/2313-7053-2020-1-8-19330Interrelation of auto-immune process, endocrine disorders and depressionM. A. Mayorova0N. N. Petrova1U. I. Stroev2L. P. Churilov3Y. Shoenfeld4Saint-Petersburg UniversitySaint-Petersburg UniversitySaint-Petersburg UniversitySaint-Petersburg UniversitySaint-Petersburg University; Zabludowicz Center for Autoimmune DiseasesDisturbances in immune and endocrine regulation are closely interrelated with development of psychiatric diseases, including affective disorders. Depression may be a characteristic of at least 23 autoimmune diseases. Negative influence on the depression development have: an increased level of proinflammatory cytokines, impairment of T-regulatory cells, kynurenine pathway shift towards production of its potentially neurotoxic metabolites, overproduction of stress hormones, hyperleptinemia, hyperprolactinemia, hypothyroidism, as well as vitamin D, calcidiol and calcitriol deficiency. In this review we analysed the development and accumulation of ideas and facts regarding the interrelation between autoimmune and affective pathology.https://www.bekhterevreview.com/jour/article/view/379autoimmunityautoimmune diseasesdepressionvitamin dhypothyroidismhyperprolactinemiakynurenine pathway |
| spellingShingle | M. A. Mayorova N. N. Petrova U. I. Stroev L. P. Churilov Y. Shoenfeld Interrelation of auto-immune process, endocrine disorders and depression Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева autoimmunity autoimmune diseases depression vitamin d hypothyroidism hyperprolactinemia kynurenine pathway |
| title | Interrelation of auto-immune process, endocrine disorders and depression |
| title_full | Interrelation of auto-immune process, endocrine disorders and depression |
| title_fullStr | Interrelation of auto-immune process, endocrine disorders and depression |
| title_full_unstemmed | Interrelation of auto-immune process, endocrine disorders and depression |
| title_short | Interrelation of auto-immune process, endocrine disorders and depression |
| title_sort | interrelation of auto immune process endocrine disorders and depression |
| topic | autoimmunity autoimmune diseases depression vitamin d hypothyroidism hyperprolactinemia kynurenine pathway |
| url | https://www.bekhterevreview.com/jour/article/view/379 |
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