Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain

Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain

Abstract Background Microglia pyroptosis, a newly identified form of inflammatory cell death, is involved in the development of neuropathic pain (NP). Botulinum toxin type A (BTX-A) has been shown to be effective in relieving NP, but the mechanisms involved have not been clarified. Methods A mice mo...

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Bibliographic Details
Main Authors: Sheng Tian, Lanxiang Wu, Heqing Zheng, Zhijuan Cheng, Jingjing Liu, Mingxu Liu, Xinping Yu, Jianglong Tu, Wei Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:The Journal of Headache and Pain
Subjects:
BTX-A
Neuropathic pain
Cblb
Microglia pyroptosis
Online Access:https://doi.org/10.1186/s10194-025-02109-w
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