Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature
The presentation of juvenile psoriatic arthritis (JPsA) has long been recognized to be clinically heterogeneous. As the definition of JPsA expanded to accommodate atypical manifestations of psoriasis in young children, studies began to reflect an increasingly clear biphasic distribution of age of on...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600877802 |
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| _version_ | 1849309129617702912 |
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| author | Matthew L. Stoll Peter A. Nigrovic |
| author_facet | Matthew L. Stoll Peter A. Nigrovic |
| author_sort | Matthew L. Stoll |
| collection | DOAJ |
| description | The presentation of juvenile psoriatic arthritis (JPsA) has long been recognized to be clinically heterogeneous. As the definition of JPsA expanded to accommodate atypical manifestations of psoriasis in young children, studies began to reflect an increasingly clear biphasic distribution of age of onset, with peaks in the first few years of life and again in early adolescence. These two subpopulations differ in gender ratio, pattern of joint involvement, laboratory findings and potentially response to therapy. Intriguingly, a similar distribution of age of onset has been observed in juvenile rheumatoid arthritis (JRA), and correlates with patterns of HLA association. While a secure classification of subpopulations within JPsA awaits improved pathophysiologic understanding, future research must consider the possibility that different disease mechanisms may be operative in distinct subsets of patients with this disorder. |
| format | Article |
| id | doaj-art-0cfb589b41594adfb96f8a8a2fb5e68c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0cfb589b41594adfb96f8a8a2fb5e68c2025-08-20T03:54:15ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01132-437738010.1080/17402520600877802Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the LiteratureMatthew L. Stoll0Peter A. Nigrovic1Division of Immunology, Program in Rheumatology, Children's Hospital Boston, Boston, MA, USADivision of Immunology, Program in Rheumatology, Children's Hospital Boston, Boston, MA, USAThe presentation of juvenile psoriatic arthritis (JPsA) has long been recognized to be clinically heterogeneous. As the definition of JPsA expanded to accommodate atypical manifestations of psoriasis in young children, studies began to reflect an increasingly clear biphasic distribution of age of onset, with peaks in the first few years of life and again in early adolescence. These two subpopulations differ in gender ratio, pattern of joint involvement, laboratory findings and potentially response to therapy. Intriguingly, a similar distribution of age of onset has been observed in juvenile rheumatoid arthritis (JRA), and correlates with patterns of HLA association. While a secure classification of subpopulations within JPsA awaits improved pathophysiologic understanding, future research must consider the possibility that different disease mechanisms may be operative in distinct subsets of patients with this disorder.http://dx.doi.org/10.1080/17402520600877802 |
| spellingShingle | Matthew L. Stoll Peter A. Nigrovic Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature Clinical and Developmental Immunology |
| title | Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature |
| title_full | Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature |
| title_fullStr | Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature |
| title_full_unstemmed | Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature |
| title_short | Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature |
| title_sort | subpopulations within juvenile psoriatic arthritis a review of the literature |
| url | http://dx.doi.org/10.1080/17402520600877802 |
| work_keys_str_mv | AT matthewlstoll subpopulationswithinjuvenilepsoriaticarthritisareviewoftheliterature AT peteranigrovic subpopulationswithinjuvenilepsoriaticarthritisareviewoftheliterature |