THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES
Aim. To study the baseline parameters of potentially atherogenic oxidativeantioxidant changes of low-density lipoproteides (LDL) with adverse 7-year longterm outcomes.Material and methods. In male population (n=1024, aged 47-73 year-old) by biochemistry we assessed the values of baseline and catalyz...
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«FIRMA «SILICEA» LLC
2016-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/516 |
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| author | Yu. I. Ragino M. I. Voevoda S. K. Malyutina V. V. Gafarov S. V. Shishkin S. N. Bogatyrev L. V. Scherbakova Ya. V. Polonskaya |
| author_facet | Yu. I. Ragino M. I. Voevoda S. K. Malyutina V. V. Gafarov S. V. Shishkin S. N. Bogatyrev L. V. Scherbakova Ya. V. Polonskaya |
| author_sort | Yu. I. Ragino |
| collection | DOAJ |
| description | Aim. To study the baseline parameters of potentially atherogenic oxidativeantioxidant changes of low-density lipoproteides (LDL) with adverse 7-year longterm outcomes.Material and methods. In male population (n=1024, aged 47-73 year-old) by biochemistry we assessed the values of baseline and catalyzation stimulated oxidation of peroxidated lipids products (LOP) in LDL, concentration of antioxidants in LDL (alpha-tocopherol, beta-carotene, retinol, xantines), concentration of antibodies to oxidized LDL (oxLDL). Then, during 7 years with the use of Registers we assessed endpoints: myocardial infarction, stroke, total and cardiovascular mortality.Results. The significant associations revealed, of the baseline LDL products content (p=0,019, Hazard Ratio, HR=1,39) and resistance of LDL to oxidation at early stage (p=0,048, HR=1,18) with the stroke cases. Also, the significant relations found of beta-carotene in LDL (p=0,034, HR=0,98) and antibodies concentration against oxLDL (p=0,041, HR=0,99) with cardiovascular mortality cases in 7 year follow-up.Conclusion. The data represents significant pathogenetic role of atherogenic oxidation-antioxidant changes of LDL in development of cardiovascular diseases and complications. |
| format | Article |
| id | doaj-art-0cfa53c7bac0466e919eb9bd384e5763 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2016-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-0cfa53c7bac0466e919eb9bd384e57632025-08-20T03:43:36Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202016-12-01012454810.15829/1560-4071-2016-12-45-48774THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALESYu. I. Ragino0M. I. Voevoda1S. K. Malyutina2V. V. Gafarov3S. V. Shishkin4S. N. Bogatyrev5L. V. Scherbakova6Ya. V. Polonskaya7Scientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSScientific-Research Institute for Therapy and Preventive Medicine of the SD RAMSAim. To study the baseline parameters of potentially atherogenic oxidativeantioxidant changes of low-density lipoproteides (LDL) with adverse 7-year longterm outcomes.Material and methods. In male population (n=1024, aged 47-73 year-old) by biochemistry we assessed the values of baseline and catalyzation stimulated oxidation of peroxidated lipids products (LOP) in LDL, concentration of antioxidants in LDL (alpha-tocopherol, beta-carotene, retinol, xantines), concentration of antibodies to oxidized LDL (oxLDL). Then, during 7 years with the use of Registers we assessed endpoints: myocardial infarction, stroke, total and cardiovascular mortality.Results. The significant associations revealed, of the baseline LDL products content (p=0,019, Hazard Ratio, HR=1,39) and resistance of LDL to oxidation at early stage (p=0,048, HR=1,18) with the stroke cases. Also, the significant relations found of beta-carotene in LDL (p=0,034, HR=0,98) and antibodies concentration against oxLDL (p=0,041, HR=0,99) with cardiovascular mortality cases in 7 year follow-up.Conclusion. The data represents significant pathogenetic role of atherogenic oxidation-antioxidant changes of LDL in development of cardiovascular diseases and complications.https://russjcardiol.elpub.ru/jour/article/view/516male populationoxidized low density lipoproteidesantioxidants7-year long-term resultsstrokecardiovascular mortality |
| spellingShingle | Yu. I. Ragino M. I. Voevoda S. K. Malyutina V. V. Gafarov S. V. Shishkin S. N. Bogatyrev L. V. Scherbakova Ya. V. Polonskaya THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES Российский кардиологический журнал male population oxidized low density lipoproteides antioxidants 7-year long-term results stroke cardiovascular mortality |
| title | THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES |
| title_full | THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES |
| title_fullStr | THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES |
| title_full_unstemmed | THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES |
| title_short | THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES |
| title_sort | relation of atherogenic oxidative antioxidant shifts in low density lipoproteides with adverse long term prognosis in males |
| topic | male population oxidized low density lipoproteides antioxidants 7-year long-term results stroke cardiovascular mortality |
| url | https://russjcardiol.elpub.ru/jour/article/view/516 |
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